ID   MUTL_RALSO              Reviewed;         636 AA.
AC   Q8XWB1;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RSc2563;
GN   ORFNames=RS00753;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AL646052; CAD16270.1; -; Genomic_DNA.
DR   RefSeq; WP_011002478.1; NC_003295.1.
DR   AlphaFoldDB; Q8XWB1; -.
DR   SMR; Q8XWB1; -.
DR   STRING; 267608.RSc2563; -.
DR   EnsemblBacteria; CAD16270; CAD16270; RSc2563.
DR   GeneID; 60502069; -.
DR   KEGG; rso:RSc2563; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..636
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177961"
FT   REGION          332..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  68732 MW;  A04687377B66A3E3 CRC64;
     MTAATPARRP IRPLPDQLIS QIAAGEVVER PASVVKELLE NALDAGATQL QIKLEEGGVR
     RIAITDNGGG IPVDELPVAL MRHATSKIGS LEELESVATL GFRGEALASI ASVAELTLTS
     RTAQDAHATQ IIAQTGRVQP ASGGVGTTVD VQHLYFNTPA RRKFLKTEQT ELGHCLEVIR
     RTALARPDVA ISVHHNGKPL EHWNAAQADM RTAAVLGTEF ARARLPFEEA AGELRLFGFA
     GLPTASRGRA DHQFFYVNGR FVRDRLLTHA VRSAYEDVLH GDRFPAYVLC LELPPEAVDV
     NVHPSKIEVR FRDSRAVHQF VYHAVQRALS RHAGEQGDSL RTDIADAPEQ PGATATPADN
     TTRWVNQMAA RQTSLGIAQP RAEYLAMMRG GSAPQPSSRP AWMADVPSAA TLFDGAASAP
     ADAAPAQASE PAAAPQADDS DDAHPLGFAV AQLHGIYVLA QNARGMVLVD MHAAHERILY
     EQLKTALEAR RIEVQPLLIP VTFAASPVEI GTAEEFGDTL DLLGFDISAV SPTTLAVRAV
     PTLLQKADAQ ALARDVLRDL QAYGGSRVLA ERQNELLATL ACHSAVRANR RLNLDEMNAL
     LRQMEATERA DQCNHGRPTW IQLTVADLDR LFLRGQ