ID   MUTL_RHIE6              Reviewed;         606 AA.
AC   B3PRD9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=RHECIAT_CH0000937;
OS   Rhizobium etli (strain CIAT 652).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=491916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIAT 652;
RA   Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P.,
RA   Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J.,
RA   Palacios R., Davila G.;
RT   "Genome diversity and DNA divergence of Rhizobium etli.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001074; ACE89922.1; -; Genomic_DNA.
DR   RefSeq; WP_012482844.1; NC_010994.1.
DR   AlphaFoldDB; B3PRD9; -.
DR   SMR; B3PRD9; -.
DR   EnsemblBacteria; ACE89922; ACE89922; RHECIAT_CH0000937.
DR   GeneID; 45956276; -.
DR   KEGG; rec:RHECIAT_CH0000937; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000008817; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..606
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096676"
FT   REGION          348..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  65169 MW;  7189121E56DD0618 CRC64;
     MAIRQLSETL INQIAAGEVI ERPASAAKEL IENALDAGAT RIEIATAGGG KALLRVSDNG
     SGMEATDLEL AVRRHCTSKI SETLEDIRTL GFRGEALPSI GSVARLNIAS RRRDSAGGHE
     IAVAGGKIVH IRPAAANPGT IVEVRDLFFA TPARLKFLKS EKAEAGAITE IVKRMAIAFP
     AVRFVLSGSD RTTLEFPATG DDHLARMAQV LGKEFRDNAI LLDAVREDIS LTGFAGVPTF
     NRGNSAHQYA FVNGRPVQDK LILSAIRGAY AETIPSGRYP VAVLSITLDP ALVDVNVHPA
     KSDVRFRDPG LVRGLIVGAI REALARDGSR AATTGASDML RAFRPGFQPH AQRPQAPWSA
     ETSPFRPYPP AAGFSERPQA SFDRLSMPTA RAELQPSPQP GAPEPAASAE TTGRYPLGAA
     RAQIHANYIV AQTEDGLVIV DQHAAHERLV FEAMRKALHS KRLASQVLLI PEIIDLPEED
     CDRLMQHAAE LSELGLAIER FGPGAIAVRE TPAMLGEVDA HGLIRQLADE IAEWDTASGL
     SAKLEYVAAT MACHGSVRSG RRLRPEEMNA LLREMEVTPG SGQCNHGRPT YIELKLSDIE
     RLFGRS