ID   MUTL_RHIEC              Reviewed;         610 AA.
AC   Q2KBX7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RHE_CH00848;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000133; ABC89659.1; -; Genomic_DNA.
DR   RefSeq; WP_011424197.1; NC_007761.1.
DR   AlphaFoldDB; Q2KBX7; -.
DR   SMR; Q2KBX7; -.
DR   STRING; 347834.RHE_CH00848; -.
DR   EnsemblBacteria; ABC89659; ABC89659; RHE_CH00848.
DR   KEGG; ret:RHE_CH00848; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..610
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010060"
FT   REGION          351..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  65292 MW;  A76F3489064B2487 CRC64;
     MAIRQLSETL INQIAAGEVI ERPASAAKEL IENALDAGAT RIEIATAGGG KALLRVSDNG
     SGMDAADLEL AIRRHCTSKI SETLEDIRTL GFRGEALPSI GSVARLSIAS RKRDSAGGHE
     IAVAGGKVLH LRPAGANPGT IVEVRDLFFA TPARLKFLKT EKAEAGAITE IVKRMAIAFP
     AVRFVLSGSD RATLEFPATG DDHLARMAQV LGKDFSDNAI ALDAVREEIS LTGFAGVPTF
     NRGNSAHQYA FVNGRPVQDK LILSAIRGAY AETIPSGRYP VAVLSIALDP ALVDVNVHPA
     KSDVRFRDPG LVRGLIVGAI REALARDGSR AATTGASDML RAFRPGFQPY GQRPQAPWSA
     ETSPSRPYQP APAFSERPQA SFDGLSTPTA RAEPQFSPDP VSPGLASPRP VAPETVGRYP
     LGAARAQIHA NYIVAQTEDG LVIVDQHAAH ERLVFEAMRK ALHSKRLASQ VLLIPEIVDI
     PEEDCDRLML HAAEFAELGL AIERFGPGAI AVRETPAMLG EVDAHGLIRQ LADEIAEWDT
     ASGLSAKLEY VAATMACHGS VRSGRRLRPE EMNALLREME VTPGSGQCNH GRPTYIELKL
     SDIERLFGRS