MUTL_RHILO
ID MUTL_RHILO Reviewed; 627 AA.
AC Q983L2;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=mll8278;
OS Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS (Mesorhizobium loti (strain MAFF 303099)).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=266835;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA Tabata S.;
RT "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT Mesorhizobium loti.";
RL DNA Res. 7:331-338(2000).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; BA000012; BAB53869.1; -; Genomic_DNA.
DR RefSeq; WP_010915495.1; NC_002678.2.
DR AlphaFoldDB; Q983L2; -.
DR SMR; Q983L2; -.
DR STRING; 266835.14027600; -.
DR EnsemblBacteria; BAB53869; BAB53869; BAB53869.
DR KEGG; mlo:mll8278; -.
DR PATRIC; fig|266835.9.peg.6614; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000552; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..627
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177962"
SQ SEQUENCE 627 AA; 66954 MW; 4F69BCB4F69A15D5 CRC64;
MPIRQLSETM INQIAAGEVI ERPASVVKEL VENALDAGAS RVEVVTAGGG LNLIRVTDDG
SGIPEPELAL AIARHCTSKL AEDINDIRSL GFRGEALPSI GSVSRLSIRS RTALGDSAAE
IGIEGGRVLP VRPAAANRGT TVEVRDLFFA TPARLKFMKG ERAESSATSD VVKRIAIAFP
AVRFTLAGSD RSTLELPATD DSPEGSLRRV AQVMGAEFPD NSIAIDAMRE GVHLTGHVSI
PSFSRANALQ QYAYVNGRPV RDKLIAGAIR GAFADVLPRD RHAVTVLFLT LDPAIVDVNV
HPAKADVRFR DPGLVRGLIV GAIRQALADA GIRSATTGAA GMMAAFRPGA ASYNHGGPAN
GHRSYEAAYR ASGSAGFDPA RSPQRPLDMQ FGDFERAGAR HGGFSEPGQA AFDTGPLVSA
DARVGQNETT ETLLGTVLGA ARAQVHENYI VAQTRDSLVI VDQHAAHERL VYEALKNALH
SRPVPSQMLL LPEIIDLPEE DAERLAMHSE TLARFGLGIE RFGPGAVAVR ETPSMLGETN
VQQLVRDLAD EIADNDTVET LKERLDKIAA TMACHGSVRS GRLLKAEEMN ALLRQMEATP
GSGTCNHGRP TYIELKLADI ERLFGRR