MUTL_RHIWR
ID MUTL_RHIWR Reviewed; 594 AA.
AC A5V3J3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Swit_0491;
OS Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC
OS 105917 / EY 4224 / RW1) (Sphingomonas wittichii).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Rhizorhabdus.
OX NCBI_TaxID=392499;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A.,
RA Richardson P.;
RT "Complete sequence of chromosome of Sphingomonas wittichii RW1.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000699; ABQ66859.1; -; Genomic_DNA.
DR RefSeq; WP_011951339.1; NC_009511.1.
DR AlphaFoldDB; A5V3J3; -.
DR SMR; A5V3J3; -.
DR STRING; 392499.Swit_0491; -.
DR EnsemblBacteria; ABQ66859; ABQ66859; Swit_0491.
DR KEGG; swi:Swit_0491; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000001989; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..594
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010083"
SQ SEQUENCE 594 AA; 63707 MW; B78D63B4776B79D1 CRC64;
MSIRRLPEHL VNRIAAGEVV ERPASALKEL VENSIDAGAR RISVSLSEGG LSAIDVADDG
CGMTPDEIAL ALERHATSKL PDDAIEAVTT LGFRGEALPS IGSVADLTIE SRVRGADGWH
RRVDHGELVG EGPAALPPGT RIRVSNLFAK VPARRKFLRS ARAEYAACVD VIKRLAMARP
DIGFTLEHEG RRAILVAPDE QRVDRVAALT DRDLAQNSVA VDFRREAVSL TGVAGLPTFN
RGVADHQFLF VNGRPVKDRL LIGAVRGAYQ DMLARDRHPV IALFVELPGD QVDVNVHPAK
TEVRFRDPGL VRGMIVGGLR AALDEAGHRS VQRPSVAALG NWQAGGLPTA SSTAPAIPNG
FAFGAAAERS GQGSVWDRVA DFAPAPMARA EPAYSPPPQQ ASYPMGVARG QVAATYIVAE
AEDGLVIVDQ HAAHERLVLE RMRRAMADGG VARQALLLPE VVELDEVGCD RLETRIAELA
EMGLELERFG PKAMLVRATP ALLGQGDVHG LIVDLADELA AYDEALSLKE RLDHVAATMA
CHGSVRAGRT LSVAEMNALL REMEVTPHSG QCNHGRPTWI KLGHGDIEKL FGRK