MUTL_RHOP5
ID MUTL_RHOP5 Reviewed; 603 AA.
AC Q07RR2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RPE_1420;
OS Rhodopseudomonas palustris (strain BisA53).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Rhodopseudomonas.
OX NCBI_TaxID=316055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BisA53;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y.,
RA Richardson P.;
RT "Complete sequence of Rhodopseudomonas palustris BisA53.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000463; ABJ05372.1; -; Genomic_DNA.
DR RefSeq; WP_011662858.1; NC_008435.1.
DR AlphaFoldDB; Q07RR2; -.
DR SMR; Q07RR2; -.
DR STRING; 316055.RPE_1420; -.
DR PRIDE; Q07RR2; -.
DR EnsemblBacteria; ABJ05372; ABJ05372; RPE_1420.
DR KEGG; rpe:RPE_1420; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..603
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010063"
SQ SEQUENCE 603 AA; 65273 MW; C6F98867181E9ABD CRC64;
MPVRQLPETI VNRIAAGEVV ERPASVVKEL VENALDAGAN RIEVFSDGGG RRRIAITDDG
GGMTRADLEL AVDRHATSKL DDEDLLAIRT LGFRGEALPS IGSVAKLSIT TRHTEEPHAW
ALAVEGGTKS PLVPAALSQG TRVEVSDLFY ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
PDVAFTLSGE ERAPVSWAAV LPGAAGRLTR LSDILGAEFR KSAIEVRSER DGVVVEGFAG
APSLTRANAL GQYLFVNGRP VRDRLIIGAV RAAYADYLPR DRHPVLALFV TCDPHEVDAN
VHPAKTEVRF RDAGLVRALI VHALKDGLSR EGQRSAAASV DGATLAAFRP GFAPPPRANW
DWRRSPSYPI AGSNAMDMAP GFAEREQAGF DVGLPSADVR NYAAPAAELI DRPLGAARTQ
IHETYIVAQT RTGLVIVDQH AAHERLVYEK LKASMASNGV QRQLLLIPEI VELDEATVEQ
LLDRAEELCS FGLAIDSFGP GAVAVREVPA LLGKANAASL LRDLAEHMAE WDEALPLERR
LLHVAATMAC HGSVRAGRIL KPEEMNALLR EMEATPNSGQ CNHGRPTYVE LTLSDIEKLF
GRR