ID   MUTL_RHOPA              Reviewed;         595 AA.
AC   Q6N1N4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RPA4371;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BX572607; CAE29812.1; -; Genomic_DNA.
DR   RefSeq; WP_011159905.1; NC_005296.1.
DR   AlphaFoldDB; Q6N1N4; -.
DR   SMR; Q6N1N4; -.
DR   STRING; 258594.RPA4371; -.
DR   PRIDE; Q6N1N4; -.
DR   EnsemblBacteria; CAE29812; CAE29812; RPA4371.
DR   GeneID; 66895504; -.
DR   KEGG; rpa:RPA4371; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q6N1N4; -.
DR   BioCyc; RPAL258594:TX73_RS22290-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..595
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010064"
SQ   SEQUENCE   595 AA;  64359 MW;  011898E77C9F5265 CRC64;
     MPVRQLPETI VNRIAAGEVV ERPASVVKEL VENAIDAGAS RIDIFSDGGG RRKIVIADDG
     SGMTQADLAL AVDRHATSKL DDEDLLQIRT LGFRGEALPS IGAVARLSIT TRHAAEPHAW
     ALRVEGGDKT PIAPAALTQG TRVEVADLFF ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDVAFTLAGE ERAPVTWAAA LPGAPGQLIR LGDILGADFR ANAIEVRAER EGVVVEGFAA
     APSLTKANAL GQYLFVNGRP VRDKLILGAV RAAYSDYLPR DRHPVVALFV TLDAREVDAN
     VHPAKTEVRF RNSGLVRALI VHALKDGLAR EGRRTAANSA SSVISTFRPA SMPPANWDWR
     SSPSYPVGGS AAPSFAERAQ AAFDVGAPSA DIRPQEVTPD LLDRPLGAAR TQIHETYIVS
     QTRDGLIVID QHAAHERIVY ERLKASLEAN GVQRQILLIP DIVEMDEATV ERLVARAEEL
     AQFGLVIESF GPGAVAVRET PSLLGKTDAS GLLRDLAEHM AEWDEALPLE RRLMHVAATM
     ACHGSVRAGR VLKPEEMNAL LREMEATPNS GQCNHGRPTY VELTLADIEK LFGRR