ID   A13CB_XENLA             Reviewed;         513 AA.
AC   Q7ZYD9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Ankyrin repeat domain-containing protein 13C-B;
GN   Name=ankrd13c-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC       receptors, regulating their biogenesis and exit from the ER.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC       Note=Associated with the cytosolic side. {ECO:0000250}.
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DR   EMBL; BC043828; AAH43828.1; -; mRNA.
DR   RefSeq; NP_001079491.1; NM_001086022.1.
DR   AlphaFoldDB; Q7ZYD9; -.
DR   SMR; Q7ZYD9; -.
DR   DNASU; 379178; -.
DR   GeneID; 379178; -.
DR   KEGG; xla:379178; -.
DR   CTD; 379178; -.
DR   Xenbase; XB-GENE-6251619; ankrd13c.S.
DR   OrthoDB; 425969at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 379178; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR021832; ANKRD13.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR12447; PTHR12447; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF11904; GPCR_chapero_1; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Chaperone; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Repeat.
FT   CHAIN           1..513
FT                   /note="Ankyrin repeat domain-containing protein 13C-B"
FT                   /id="PRO_0000240649"
FT   REPEAT          83..114
FT                   /note="ANK 1"
FT   REPEAT          115..144
FT                   /note="ANK 2"
FT   REPEAT          148..177
FT                   /note="ANK 3"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          55..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  58779 MW;  7CEC5B3D5032FF75 CRC64;
     MTGEKIRSLH RDQKPSKDED LLEPDEEATA DGTFTRTSKL KSSKMFSNHK VIRSPSNPAL
     LQNHHHHHQQ QISPMTPGES KTDVYFPVHE CVIKGDIRKL SSLIRSHNIG QKDNHGNTPL
     HLAVMLGNKE CAHLLLAHNA PVKVKNAQGW SPLAEAISYG DRQMITALLR KLKQQSRESV
     EEKRPRLLKA LKELGDFYLE LHWDFQSWVP LLSRILPSDA CKIYKQGINI RLDTTLIDFT
     DMKCQRGDLS FIFNGDAAPS ESFVVLDNEQ KVYQRIHHEE SEMETEEEVD ILMSSDIYSA
     TLSTKSITFS RAQTGWLFRE DKTERVGNFL ADFYTVNGLI LESRKRREHL TEEDILRNKA
     IMESLSKGGN LMEQTFEPVR RPSLTPPPPN TITWEEYISA ENGKAPHLGR ELVCKENKKT
     FKATIAMSQD FPLEIESLLN VLEVIAPFKH FNKLREFVQM KLPPGFPVKL DIPVFPTITA
     TVTFQEFHYG EFEDAIFTIP DDYKEDPSRF PDL