ID   MUTL_RHOPT              Reviewed;         595 AA.
AC   B3Q7Y9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Rpal_4855;
OS   Rhodopseudomonas palustris (strain TIE-1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=395960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TIE-1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Emerson D.,
RA   Newman D.K., Roden E., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris TIE-1.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001096; ACF03344.1; -; Genomic_DNA.
DR   RefSeq; WP_012497571.1; NC_011004.1.
DR   AlphaFoldDB; B3Q7Y9; -.
DR   SMR; B3Q7Y9; -.
DR   PRIDE; B3Q7Y9; -.
DR   EnsemblBacteria; ACF03344; ACF03344; Rpal_4855.
DR   KEGG; rpt:Rpal_4855; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; RPAL395960:RPAL_RS24015-MON; -.
DR   Proteomes; UP000001725; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..595
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096678"
SQ   SEQUENCE   595 AA;  64247 MW;  1D80C7E4211B4951 CRC64;
     MPVRQLPEII VNRIAAGEVV ERPASVVKEL VENAIDAGSS RIDIFSDGGG RRKIVIADDG
     SGMTAADLAL AVDRHATSKL DDEDLLQIRT LGFRGEALPS IGAVAKLSIT TRHASEPHAW
     TLRVEGGDKT PIAPAALSQG TRVEVADLFF ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDIAFTLAGE ERAPVTWAAA LPGAPGQLIR LGDILGADFR ANAIEVRAER EGVVVEGFAA
     SPALTKANAL GQYLFVNGRP VRDKLILGAV RAAYSDYLPR DRHPVVALFV TLDSREVDAN
     VHPAKTEVRF RNAGLVRALI VHALKDGLAR EGRRTAANSA GSVISTFRPA SMPPANWDWR
     ASPSYPVGGS AAPSFAERAQ AAFDVGAPSA DIRPTEVTPD LLDRPLGAAR TQIHETYIVS
     QTRDGLIVVD QHAAHERIVY ERLKASLEAN GVQRQILLIP DIVEMDEATV ERLVARGEEL
     AKFGLVIESF GPGAVAVRET PSLLGKTDAG GLLRDLAEHM AEWDEALPLE RRLMHVAATM
     ACHGSVRAGR VLKPEEMNAL LREMEATPNS GQCNHGRPTY VELTLTDIEK LFGRR