ID   MUTL_RHORT              Reviewed;         629 AA.
AC   Q2RQ52;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Rru_A2946;
OS   Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS   NCIMB 8255 / S1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=269796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=21886856; DOI=10.4056/sigs.1804360;
RA   Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA   Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA   Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA   Roberts G.P., Reslewic S., Schwartz D.C.;
RT   "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL   Stand. Genomic Sci. 4:293-302(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000230; ABC23743.1; -; Genomic_DNA.
DR   RefSeq; WP_011390696.1; NC_007643.1.
DR   RefSeq; YP_428030.1; NC_007643.1.
DR   AlphaFoldDB; Q2RQ52; -.
DR   SMR; Q2RQ52; -.
DR   STRING; 269796.Rru_A2946; -.
DR   PRIDE; Q2RQ52; -.
DR   EnsemblBacteria; ABC23743; ABC23743; Rru_A2946.
DR   KEGG; rru:Rru_A2946; -.
DR   PATRIC; fig|269796.9.peg.3054; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   PhylomeDB; Q2RQ52; -.
DR   Proteomes; UP000001929; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..629
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010067"
SQ   SEQUENCE   629 AA;  66131 MW;  F9242D7753D03A84 CRC64;
     MTIRLLPPVL VNRIAAGEVV ERPASAVKEL VENAIDAGAS RIDITMTDGG RARILVVDDG
     RGMDPGELSL AVERHATSKL PGDDLLDIHT LGFRGEALPS IGSVARLTLT SRAAGAGDAW
     ALTVEGGAKG EPEPASHPQG TRVEVRDLFY ATPARLKFLK APRTEQMHAV DVVHRLAMAH
     PAVGFTLSDG TRQQIRLSGA QGELFEARLT RLGAILGREF SDNAIAIEAE REGIRLTGHA
     ALPTYNKATS AGQYLFVNGR PVRDKLLHGA VRGAYQDVLA HDRNAVLALY LDLPPEMVDV
     NVHPAKAEVR FRDPGLVRGL IIGALRHALA AAGHRASSTV SLAALGALRP AQGSGAPALP
     WGAGGYGGGA SHPGLEERRS AYAAQAPAGT PDPWAGRGMG AGGGSGQAAM AWLAGAPPAA
     PRLAGEPEAP PTGAEDFPLG AARGQIHDTY IIAQTRDGVV IVDQHAAHER LVMERMKAAL
     AERGEVARQI LLLPEVVELD EPGAVRVATA AAELAKLGLV VEGFGPGAVV VREVPALLGD
     TDVKGLVADL AEGLAEWGTA QALEDRLGDV VATMACHGSV RAGRRLRIEE MNALLRDMER
     TPRAGQCNHG RPTYVELRLG DIERLFGRR