ID   MUTL_RICAH              Reviewed;         609 AA.
AC   A8GQA9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=A1C_06805;
OS   Rickettsia akari (strain Hartford).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=293614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hartford;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia akari.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000847; ABV75584.1; -; Genomic_DNA.
DR   RefSeq; WP_012150212.1; NC_009881.1.
DR   AlphaFoldDB; A8GQA9; -.
DR   SMR; A8GQA9; -.
DR   STRING; 293614.A1C_06805; -.
DR   EnsemblBacteria; ABV75584; ABV75584; A1C_06805.
DR   KEGG; rak:A1C_06805; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006830; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..609
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010068"
FT   REGION          364..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  68982 MW;  1BBD78DD673EC2F6 CRC64;
     MTIKFLSENT INRIAAGEVI ERPASVVKEL VENAVDAGST KIDIILERAG KNLIIISDDG
     IGMTDKELEI AVERHTTSKL DESDFLNIHT FGFRGEALPS IAAISKMLIT SKKQGYDKAF
     QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR SDKTELVATV DVVKKIALAH
     PKISFSLTHD DRNLLKFKGH NKDVETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT
     SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPQLVDV
     NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NTSHVTSTTI ASDALQLFKN HLVNKQPSVS
     KAVSVNSKPT DYRPAMSPSF KSTPNTDCQK LIDTLPHAKI EQEVERRIER EQQAHKQYKL
     GAAKAQLHTT YIISQTEDSI VITDQHAAHE RLGYEKIKDY LKTEELIRQR LLIPEIVELP
     NERNADSLYE NREKLYKLGL TLEKFGEKSI IVTEIPNILG DVNVQKLIHD LADHLSDFGE
     NIALTELIEH VTETYACHYS IRAGRKLSAD EMNALLRQME NTPFSGQCNH GRPTYIELKL
     KDIERLFGR