ID   MUTL_RICB8              Reviewed;         611 AA.
AC   A8GY89;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=A1I_07705;
OS   Rickettsia bellii (strain OSU 85-389).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=391896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OSU 85-389;
RA   Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.;
RT   "Complete genome sequencing of Rickettsia bellii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000849; ABV79839.1; -; Genomic_DNA.
DR   RefSeq; WP_012152291.1; NC_009883.1.
DR   AlphaFoldDB; A8GY89; -.
DR   SMR; A8GY89; -.
DR   KEGG; rbo:A1I_07705; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..611
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010069"
FT   REGION          364..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  68915 MW;  CF241C31FC42F5DD CRC64;
     MTIKLLSEST INRIAAGEVI ERPASVVKEL VENAVDAGST KIDIILERAG KNLIIISDDG
     VGMTDKELEI AVERHTTSKL DETDFLNIHT FGFRGEALPS IAAISKMLIT SKKRDNQKAF
     QIKLIGGDEK QIAPAIHNEG TKIEIRDLFF ATPARLKFLR TDKTELAATV DVVKKIALAH
     PEISFSLTHD GKTLLKLKGQ NKDAENNLKQ RIIDVIGEDF IKNASYIDFK SPDFSIYGYT
     SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYML RDRYPLCAIF LQIDPQLVDV
     NVHPAKAEVR FHDPNYVRNL LIDSIKNALS NKSHIASTTI ASSAIELFKN PFVNKEPAIS
     KPLNVNSKPS KYRPATSPTV PKYTPNNSCQ KLIDTLPHAR IEQEVEQRIQ NEPQKSSQYR
     LGAAKAQLHT TYVISQTEDS IVITDQHAAH ERLGYEKIKN YIKNEELIKQ RLLIPEIVEL
     PDEKRADILY ENKDKLSKLG LSLEKFGEKS IIVTEIPNIL GDINVQKLIQ DLADHLAECG
     ENIALTELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPFSGQCN HGRPTYIELK
     LKDIERLFGR K