ID   MUTL_RICCK              Reviewed;         610 AA.
AC   A8F0A4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=A1E_05630;
OS   Rickettsia canadensis (strain McKiel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=293613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=McKiel;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia canadensis.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000409; ABV74037.1; -; Genomic_DNA.
DR   RefSeq; WP_012149231.1; NC_009879.1.
DR   AlphaFoldDB; A8F0A4; -.
DR   SMR; A8F0A4; -.
DR   STRING; 293613.A1E_05630; -.
DR   EnsemblBacteria; ABV74037; ABV74037; A1E_05630.
DR   KEGG; rcm:A1E_05630; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007056; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..610
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010070"
SQ   SEQUENCE   610 AA;  69138 MW;  5A80120F099C6FE0 CRC64;
     MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KINIILERAG KNLIIISDDG
     IGMTDKELEI AVERHTTSKL DESDFLKIHT FGFRGEALPS IAAISKMLIT SKKRGTDKAF
     QIKLIGGNEK QITISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELAVTV DIVKKIALAH
     PEISFSLTND SKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK ILDFSICGYT
     SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPQFVDV
     NVHPAKAEVR FHDPNYVRNL LIEAIKNALA NKSHVTSTTI ASDTLKLFKN PLINKQPTIN
     KEVNVNSKSV DYRSYSSANT PKILQNHICQ KLIDTLPHAK VEQEVENRIE HKQQIHKQYK
     LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKS YIKMDELIKQ RLLIPEIVEL
     PNEKRADCLY DHREKLSKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFS
     ENVALMELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPFSGQCN HGRPTYIELK
     LKDIERLFGR