ID   MUTL_RICFE              Reviewed;         609 AA.
AC   Q4UJQ1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RF_1387;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000053; AAY62238.1; -; Genomic_DNA.
DR   RefSeq; WP_011271686.1; NC_007109.1.
DR   AlphaFoldDB; Q4UJQ1; -.
DR   SMR; Q4UJQ1; -.
DR   STRING; 315456.RF_1387; -.
DR   EnsemblBacteria; AAY62238; AAY62238; RF_1387.
DR   KEGG; rfe:RF_1387; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..609
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000274890"
SQ   SEQUENCE   609 AA;  68766 MW;  A69F329F3BE34492 CRC64;
     MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDAGST KIDIILERAG KNLIIISDDG
     IGMTDKELEI AVERHTTSKL DESDFLNIHT FGFRGEALPS IAAISKMLIT SKKQGADKAF
     QIKLIGGNEK QVTVSVHNEG TKIEIRDLFF ATPARLKFLR ADKTELAATV DVVKKIALAH
     PEISFSLTHD DRNLLKFKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT
     SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPQLVDV
     NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDALQLFKN PLVNKQPSVS
     KAVSVNSKPA DYRPAMSPSF KPTPNTACQK LIDTLPHAKI EQEVERRIEH EQQVHKQYKL
     GAAKAQLHTT YIISQTEDSI VITDQHAAHE RLGYEKIKDY LKTEELIKQR LLIPEIVELP
     NERKADCLYE NREKLYKLGL TLEKFGEKSI IVTEIPNILE DVNVQKLIQD LADHLSDFGE
     NIALTELIEH VTETYACHYS IRAGRKLSAD EMNALLRQME NTPFSGQCNH GRPTYIELKL
     KDIERLFGR