ID   MUTL_RICPR              Reviewed;         595 AA.
AC   Q9ZC88;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=RP880;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235273; CAA15302.1; -; Genomic_DNA.
DR   PIR; F71650; F71650.
DR   RefSeq; NP_221226.1; NC_000963.1.
DR   RefSeq; WP_004596727.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZC88; -.
DR   SMR; Q9ZC88; -.
DR   STRING; 272947.RP880; -.
DR   PRIDE; Q9ZC88; -.
DR   EnsemblBacteria; CAA15302; CAA15302; CAA15302.
DR   KEGG; rpr:RP880; -.
DR   PATRIC; fig|272947.5.peg.918; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..595
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177965"
SQ   SEQUENCE   595 AA;  67477 MW;  E61FCFBD45D267CC CRC64;
     MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAIDGGST KIDIILERAG KNLIIVSDDG
     IGMTDKELEI AVKRHTTSKL NESDFFNIHT FGFRGEALAS IAAISKMLIT SKKREADKAF
     QIKLIGGNKQ QITVSVHNEG TKIEVRDLFF ATPARLKFLR SDKTELAASI DIVKKIALAH
     PRISFNLIHD NKNLLKLKGQ NKDSETNLKQ RIIDVIGDVF IKNAAYIDFK TPDFSICGYT
     SIPTYNKASS EDQFLFINNR PIKDKLLQVA LRVAYQDYLA RDRYALCVIF LQIDPQLVDV
     NVHPAKAEVR FHDPNYVRNI LIEAIKNALT NKSQITATTI GSDKNSLVNK EPTIHKATNV
     NSKASEYTSF NFKRNTAYHT LPYGKIEQEV GKCIEHNNQS HKQYKFGVAK AQLHTTYIIS
     QTEDSIVIID QHAAYERLGY AKIKYCLKNG ELVKQRLLIP EIVELSSQKK ADCLYENREK
     LFKLSLTIEK FGEKSIIVTE IPNILGDVNV QKLIQDLADH LSDFAKNMPL KELIEHVIKI
     YICHYSIRAA RKLSADEMNS LLRQMENMSF SAQCNNNRPT YIELKLKDIE LLFRL