ID   MUTL_RICRS              Reviewed;         610 AA.
AC   A8GU58;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=A1G_07470;
OS   Rickettsia rickettsii (strain Sheila Smith).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=392021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheila Smith;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia rickettsii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000848; ABV76933.1; -; Genomic_DNA.
DR   RefSeq; WP_012151467.1; NC_009882.1.
DR   AlphaFoldDB; A8GU58; -.
DR   SMR; A8GU58; -.
DR   EnsemblBacteria; ABV76933; ABV76933; A1G_07470.
DR   KEGG; rri:A1G_07470; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006832; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..610
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010071"
SQ   SEQUENCE   610 AA;  68868 MW;  409913508A11D626 CRC64;
     MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG KNLIIISDDG
     IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS IAAISKMLIT SKKRDADKAF
     QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELAATV GVVKKIALAH
     PKISFSLTHD GKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT
     SSPTYNRASS EDQFLFINNR PVKDKLLQIA LRVAYQDYLA RDRYPICAIF LQINPQLVDV
     NVHPAKAEVR FHDPDYVRNL LIEAIKNALT NKSHVTSTTI ASDALELFKN PLVNKQSPVS
     KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK IEQEVENRIE HEQQIRKQYK
     LGAAKAQLHT TYIISQTEDS IVITDQHAAH KRLGYEKIKH YLKTEELIKQ RLLIPEIVEL
     PNEKKADCLY DHREKLYKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG
     KNIALTELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTLLSGQCN HGRPTYIELK
     LKDIERLFGR