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MUTL_RIPO1
ID   MUTL_RIPO1              Reviewed;         561 AA.
AC   B7JY11;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=PCC8801_1937;
OS   Rippkaea orientalis (strain PCC 8801) (Cyanothece sp. (strain PCC 8801)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Rippkaea; Rippkaea orientalis.
OX   NCBI_TaxID=41431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 8801;
RX   PubMed=21972240; DOI=10.1128/mbio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001287; ACK65975.1; -; Genomic_DNA.
DR   RefSeq; WP_012595247.1; NC_011726.1.
DR   AlphaFoldDB; B7JY11; -.
DR   SMR; B7JY11; -.
DR   STRING; 41431.PCC8801_1937; -.
DR   PRIDE; B7JY11; -.
DR   EnsemblBacteria; ACK65975; ACK65975; PCC8801_1937.
DR   KEGG; cyp:PCC8801_1937; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_3; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008204; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..561
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192168"
SQ   SEQUENCE   561 AA;  62754 MW;  5A881610E615D0EF CRC64;
     MSSPIQPLPL NVINLIAAGE VIDSIAAVVR ELVENALDAG ATRLVISLFP ESWRVQVADN
     GTGMTLADLR HCALPHSTSK IHQLDDLWKI TTLGFRGEAL HSLAQVADLE IASRCTSDGV
     GWCLRYQSSG EPLREEPTAI APGTIVTVGN LFGKMPVRRQ GLPAISTQLK AVQSFIENMA
     LCHPQVTWQV WHNQRLWLNI SPGKTPQQIL PQLLKGVHYH DLQFVSQGVK SPQESTQKDL
     DLIEVTLGLP DRCHRHRPDW VKVGINGRIV RSPPVEQAIL VAFSRTLPKD RFPVCFIHLT
     LCPSQIDWNR HPAKVEIYLH SLDFWQEQVS KLIEQGLRLS PQTLASAAQN QRVGKLLKAS
     EEKASYRVDA KDHQTDANAV GLMPLKAVAQ VRNTYIMAEH STGLWLIEQH IAHERVLYET
     LQDNWQLIPL ETPIILTKLS DNQVEQLARI GLEIEVFGEQ LWAVRTVPKL LSTREDCPEA
     LVELSIGGDL QTAQVAVACR SAIRNGTPMT LSQMQELLDQ WKTTRNPATC PHGRPIYLSL
     EESSLSRFFR RHWVIGKSHG I
 
 
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