ID   MUTL_SERP5              Reviewed;         624 AA.
AC   A8G8U7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Spro_0429;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000826; ABV39537.1; -; Genomic_DNA.
DR   RefSeq; WP_012004892.1; NC_009832.1.
DR   AlphaFoldDB; A8G8U7; -.
DR   SMR; A8G8U7; -.
DR   STRING; 399741.Spro_0429; -.
DR   EnsemblBacteria; ABV39537; ABV39537; Spro_0429.
DR   KEGG; spe:Spro_0429; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..624
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058149"
FT   REGION          360..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  69590 MW;  3DFC1F4B559D31FB CRC64;
     MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
     SGIGKDDLAL ALARHATSKI STLDDLEAIV SLGFRGEALA SISSVSRLTL TSRTAEQNEA
     WQAYAEGRDQ AVTVKPAAHP IGSTLEVLDL FYNTPARRKF MRTEKTEFGH IDEVVRRIAL
     ARFDVAINLS HNGKLMRQYR AAKDESQYER RLGSICGPAF LQHALNISWQ HGDLTIRGWV
     ADPAGARQLG EMQYCYVNSR MMRDRLINHA IRQAYQDQLK DDQQPAYVLY LEVDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQAVTTVLQ QVGNAPLPLT DETEQQPTPV WQPENRVAAG
     GNHFSQPAPR RETASTEPAV ARERAPQPAY HSGSGYQKRE GELYGKLLQA TPVAEPRQEA
     PKQPLFPPVK TEQETPLAGS QHSFGRVLMI YPPCYALIEN GQQLMLLNLP VAERWLRQAQ
     LNPSQEGLRP QPLLIPIKLT LNKQEAAACI HHQPLLVTMG LDLQVDHGRV TLRAVPLPLR
     QQNLQKLIPE LLGYLAEHQE MSPAVLATWF ARHLGSEHEQ WNTSQAIQLL TDVERLCPQL
     VKSPPSGLLQ PVDLQAALTA LRHD