ID   MUTL_SHEAM              Reviewed;         650 AA.
AC   A1SA23;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sama_3027;
OS   Shewanella amazonensis (strain ATCC BAA-1098 / SB2B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=326297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1098 / SB2B;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Fredrickson J.,
RA   Richardson P.;
RT   "Complete sequence of Shewanella amazonensis SB2B.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000507; ABM01230.1; -; Genomic_DNA.
DR   RefSeq; WP_011761134.1; NC_008700.1.
DR   AlphaFoldDB; A1SA23; -.
DR   SMR; A1SA23; -.
DR   STRING; 326297.Sama_3027; -.
DR   EnsemblBacteria; ABM01230; ABM01230; Sama_3027.
DR   KEGG; saz:Sama_3027; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000009175; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..650
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076709"
FT   REGION          374..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  71717 MW;  D5DC27F2E6438F30 CRC64;
     MAIQVLPPQL ANQIAAGEVV ERPASVIKEL VENSLDAGAT RVDIDIDKGG SKLIRIRDNG
     GGIPKAELAL ALARHATSKV QTLEDLEAIL SFGFRGEALA SISSVSRLTL TSRTTEQAEA
     WQAYAEGSEV AIRVMPAAHP VGTTIEVADL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     IRSDVHFSLS HNGKPVRQYR CAATDTQYLQ RLAQVAGRAF ADSAIKVDCQ HDGMGLSGYL
     QSPALSDMVD CHYFYVNGRL IRDRLVNHAV RQAFGELGTF EQPAFVLSLT LDPHQVDVNV
     HPAKHEVRFH QARYVHDFIL QVLQSALSQM QDLPLAEELP RAQESPASVR EHTAGYAPYT
     FNRDAATEAA GVLSSLPDTQ RSQRQPEKAA SGQRSSVDAG LSQGSSAHRA SQTGLGQSGN
     AATFETSERH GSGYSGAGQG QRYVRDQLSG QQRQAAQYYA ELLHTPEVVS TSGSLQAGLP
     MPPLLAGRYW VLAQDEHLRL LSISDAAKAL VVQEILSKLP TGLVGQPLLM PVAVAADADW
     TMILAERESL LRRLGLELTI RYQQLIIKKV PPYLRDSQLA KLIPEFLEWI KLEVPADEAL
     CHWLAQYVTG FDAAPKVWQR IQSLEATERN KILESARDLP WQTWLDEYKH