ID   MUTL_SHEB5              Reviewed;         638 AA.
AC   A3D022;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sbal_0556;
OS   Shewanella baltica (strain OS155 / ATCC BAA-1091).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=325240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS155 / ATCC BAA-1091;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Brettar I.,
RA   Klappenbach J., Konstantinidis K., Rodrigues J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Shewanella baltica OS155.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000563; ABN60085.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3D022; -.
DR   SMR; A3D022; -.
DR   STRING; 325240.Sbal_0556; -.
DR   PRIDE; A3D022; -.
DR   EnsemblBacteria; ABN60085; ABN60085; Sbal_0556.
DR   KEGG; sbl:Sbal_0556; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   Proteomes; UP000001557; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..638
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010074"
FT   REGION          398..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  70304 MW;  BB3D3BA3D16DD9D6 CRC64;
     MMGIQILPPQ LANQIAAGEV VERPASVVKE LVENSLDAGA SRVDIEIDKG GSKLIKIRDN
     GSGIPKDELA LALSRHATSK LHTLDDLEAI LSFGFRGEAL ASISSVSRLT LTSRTADQTE
     AWQAHAEGAD MAVKVMPAAH PVGSTIEVVD LFFNTPARRR FLKSDKTEFT HIDEWLKRIA
     LVRGDIHFTL THNGKMVRNY RPAMNEAQYL QRLTQVCGRP FAEQALKIEC QHDDLRLSGY
     LQSPWSPVIS DTHYFYVNGR LIRDRLVNHA VRQAFAQKAE LEQPGYVLML DIDPHQVDVN
     VHPAKHEVRF HQSRYVHDYI LQALQSALEE AGELNFVHSS SLDEVEDVFV DAPTSATEIS
     APFVLGADSA QVNVPADTLE SAQPLVASAV QVKSAGAGRE GTSFGTQTNA FGSMATPRDN
     SRGSYSAGES RQRTELPSKA AIASYGALLQ TPSYSVKDQD YQPSLPMPAI LDGQYWVMAT
     ADKLSLLPIK SVALATRCQE IEAKLATGLI GQPLLMPVSV AADADWQAVL DEHDTLIRQL
     GLELTIRYQQ LIIKKVPPYI RESQLAKVIP EWLQSLRFET PAPSALAFWL AKHSLTGFVS
     APEIWAAFSQ LAEEKKQLIA NKAILLPWQS WLEEQASE