ID   MUTL_SHEB9              Reviewed;         638 AA.
AC   A9L3W1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Sbal195_3895;
OS   Shewanella baltica (strain OS195).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=399599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS195;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Brettar I.,
RA   Rodrigues J., Konstantinidis K., Klappenbach J., Hofle M., Tiedje J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Shewanella baltica OS195.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000891; ABX51055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9L3W1; -.
DR   SMR; A9L3W1; -.
DR   EnsemblBacteria; ABX51055; ABX51055; Sbal195_3895.
DR   KEGG; sbn:Sbal195_3895; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   Proteomes; UP000000770; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..638
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076710"
FT   REGION          404..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  70221 MW;  6C9414FB1AC765F5 CRC64;
     MMGIQILPPQ LANQIAAGEV VERPASVVKE LVENSLDAGA SRVDIEIDKG GSKLIKIRDN
     GSGIPKDELA LALSRHATSK LHTLDDLEAI LSFGFRGEAL ASISSVSRLT LTSRTADQTE
     AWQAHAEGAD MAVKVMPAAH PVGSTIEVVD LFFNTPARRR FLKSDKTEFT HIDEWLKRIA
     LVRGDIHLTL THNGKTVRNY RPAMNEAQYL QRLTQVSGRP FAEQALKIEC QHDDLRLSGY
     LQSPWSPVIS DTHYFYVNGR LIRDRLVNHA VRQAFAQKAE LEQPGYVLML DIDPHQVDVN
     VHPAKHEVRF HQSRYVHDYI LQALQSALEE AGELNFVHSS SLDEVEDVFV DAPTSATEIS
     APFVLGADSA QVNVPADTLE SAQPLVASAV QVKSAGAGRE GASFGTQTNA FGSMATPRDN
     SRGNYSAGES RQRTELPSKA AIASYGALLQ TPSYSVKDQD YQPSLPMPAI LDGQYWVMAT
     ADKLSLLPIK SVALATRCQE IEAKLATGLI GQPLLMPVSV AADADWQAVL DEHDTLIRQL
     GLELTIRYQQ LIIKKVPPYI RESQLAKVIP EWLQSLRFET PAPSALAFWL AKHSLTGFVS
     APEIWAAFSQ LAEEKKQLIA NKAILLPWQS WLEEQASE