ID   MUTL_SHEDO              Reviewed;         665 AA.
AC   Q12J93;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sden_3207;
OS   Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS217 / ATCC BAA-1090 / DSM 15013;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Shewanella denitrificans OS217.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000302; ABE56483.1; -; Genomic_DNA.
DR   RefSeq; WP_011497628.1; NC_007954.1.
DR   AlphaFoldDB; Q12J93; -.
DR   SMR; Q12J93; -.
DR   STRING; 318161.Sden_3207; -.
DR   EnsemblBacteria; ABE56483; ABE56483; Sden_3207.
DR   KEGG; sdn:Sden_3207; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001982; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..665
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076711"
FT   REGION          348..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  73835 MW;  218BA12D7F8E6EA7 CRC64;
     MPIHILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RVDIDIDKGG SKLIRIRDNG
     SGIPKDELAL ALSRHATSKV HSLDDLEAIL SFGFRGEALA SISSVARLTL TSKTAEQTEA
     WQAHAEGSQM DVSLMPAAHP QGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAI
     VRTDIHFSLT HNGKLVRQYR AANTDIQMQQ RLSQICGRAF AEQAITLACE HDGLSLEGYI
     QSPHDNSVTD TNYFYVNGRL VRDKLVNHAV RQAFAEHQWH QQPSYVLKLT LDPHQVDVNV
     HPAKHEVRFH QSRYVHDFIL QALQSALAQF PAKGSQAEYD FEQDNGSLEA TAASNPDNGL
     SPSRGHAEEG DFSNSVAYAA NAASVHRGST SSERKASAGV SQFGRIPSSQ GDYQPQDNSR
     YTPKRYSTNA ASTNTASNYS HSTSAPVSRQ ALEGYAQLLA TPEIVSSSNQ YVADKNQEFK
     DVNESGSTPK VAAMPAVLAG QYWVITQGEC LRLLPLQAVR LWLRQKEISH KLPTGLVSQP
     LLMPVAVKAD KHWGEILLER ESLLRQLGLE LTIRYQQLII KKVPPYLRES QLAVLIPELL
     QWVEHQVPAI PALSAWLAKH GQKHEQSLTD TWEGFCLLSE PEQQVLLEKA KVLPWQAWLE
     ESQSE