ID   MUTL_SHEFN              Reviewed;         619 AA.
AC   Q07XW5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sfri_3313;
OS   Shewanella frigidimarina (strain NCIMB 400).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318167;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 400;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H.,
RA   Newman D., Tiedje J.M., Zhou J., Romine M.F., Culley D.E., Serres M.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.;
RT   "Complete sequence of Shewanella frigidimarina NCIMB 400.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000447; ABI73149.1; -; Genomic_DNA.
DR   RefSeq; WP_011638752.1; NC_008345.1.
DR   AlphaFoldDB; Q07XW5; -.
DR   SMR; Q07XW5; -.
DR   STRING; 318167.Sfri_3313; -.
DR   EnsemblBacteria; ABI73149; ABI73149; Sfri_3313.
DR   KEGG; sfr:Sfri_3313; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000684; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..619
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076712"
SQ   SEQUENCE   619 AA;  68934 MW;  63A462C858EC4DEA CRC64;
     MAIQLLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RVDIDIDKGG SKLIRIRDNG
     AGIAKDELAL ALSRHATSKV HTLDDLEAIL SFGFRGEALA SISSVSRLTL TSKTAEQSEA
     WQAYAEGSQM DVKVTPAAHP QGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAI
     VRSDIHFTLT HNAKLVRQYR PANTDIQTQQ RLAQICGRAF ADQALSIACE HDDFVLTGYL
     QSPQDTVITD TNFFYVNGRL IRDRLVNHAV KQAFAEYGIE HQPGYVLMLS LDPHQVDVNV
     HPAKHEVRFH QSRYVHDFIL QAVRSALVEM PALPLSDELE HHDNVAPMHT ESNLMHDVKV
     VDTAEDEFTL NHGSSKAINS VSQFGSMHVP GKNNGLSGGY SAAIKPSYDK KPSSASSAQT
     KTAIANYGQL LHTPMNSAVS YVHEAAPQVT MPPLLAGEHW VICKDDKLSL LPIKSVLLAV
     RKKDVETKLA NGLVSQPLLM PVSIAADLDW IETLAVRDQL LRQMGIELTI RFQQLIIKKV
     PPYLRECQLA IVIPELLQWI QLEQPTQSAI VGWLAQQSLS QFEPAQALWL QFCSLDDETQ
     QTCYAQERII PWQNWMKDN