ID   MUTL_SHEHH              Reviewed;         637 AA.
AC   B0TU66;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Shal_3636;
OS   Shewanella halifaxensis (strain HAW-EB4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=458817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella halifaxensis HAW-EB4.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000931; ABZ78177.1; -; Genomic_DNA.
DR   RefSeq; WP_012278696.1; NC_010334.1.
DR   AlphaFoldDB; B0TU66; -.
DR   SMR; B0TU66; -.
DR   STRING; 458817.Shal_3636; -.
DR   EnsemblBacteria; ABZ78177; ABZ78177; Shal_3636.
DR   KEGG; shl:Shal_3636; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001317; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..637
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076713"
FT   REGION          343..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   637 AA;  70500 MW;  C6AD13A488B1288B CRC64;
     MAIEKLPPQL ANQIAAGEVV ERPASVIKEL VENSLDAGAT RVDIEIEKGG SKLIRIRDNG
     SGIPKADLCL ALSRHATSKL KSLDDLEAIL SFGFRGEALA SISSVSRLIL TSRTAEQAEA
     WQAHAEGTEM AVKVLPAAHP VGSTVEAVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     ARRDIHFTLK HNGKTVRNYR PANTESQYIQ RLALVCGKAF AETCLRIECQ HNDLSLSGYL
     QSPSSANGYS ETQYFYVNGR LVKDRLVNHA VRQAFAQYAE GVSPGYVLML DLDPHQVDVN
     VHPAKHEVRF HQSRYVHDFI LQALQSAISQ SMELALNNEP EIQQSPDRQV SPTRGAVTAP
     LYSESIERKP SVSYDVRDSH SVTNQRDYSS GSSSYRSPLK PSARNGDVSL PSQSSIRAYG
     ELLSTQSSST HSDRVLSTQQ NNYAVRSPAG NQNGLAASNS HAASMPAVIA GEFWVLVRDD
     KISLLSISMV ARAVLKAEIA AKFSQGLVGQ PLLMPVAVAV DDDWLAIIEN REQLLRKLGI
     ELSIRLGQLI IKKVPPYLRN SQLAVLIPEL LQWIQLELPS DAAVVKWLAE QGANRFTSAG
     EAWFGLNALP DDVQRELYNL SQDLPWEQWM KENQSDR