ID   MUTL_SHEON              Reviewed;         631 AA.
AC   Q8EJ70;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SO_0601;
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1;
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J.,
RA   Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J.,
RA   Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V.,
RA   Smith H.O., Venter J.C., Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE014299; AAN53679.1; -; Genomic_DNA.
DR   RefSeq; NP_716234.1; NC_004347.2.
DR   RefSeq; WP_011070932.1; NZ_CP053946.1.
DR   AlphaFoldDB; Q8EJ70; -.
DR   SMR; Q8EJ70; -.
DR   STRING; 211586.SO_0601; -.
DR   PaxDb; Q8EJ70; -.
DR   KEGG; son:SO_0601; -.
DR   PATRIC; fig|211586.12.peg.580; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   PhylomeDB; Q8EJ70; -.
DR   BioCyc; SONE211586:G1GMP-571-MON; -.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..631
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076715"
FT   REGION          337..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  70402 MW;  C27977306F3EE4E6 CRC64;
     MGIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAS RIDIEIDKGG SKLIKIRDNG
     SGIPKEELAL ALSRHATSKL HSLDDLEAIL SFGFRGEALA SISSVSRLTL TSRTAEQSEA
     WQAYAEGVEM AVKVMPAAHP VGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRGDIHFTLT HNGKTVRNYR PAMNEPQYLQ RLTQVAGRPF ADEALRVECQ HDDLRLSGYL
     QSPWSTVLTD THYFYVNGRL VRDRLVNHAV RQAFAQKAEV EQPGYVLMLD IDPHQVDVNV
     HPAKHEVRFH QSRYVHDYIL QALQSALEEA GELRFEPHSP QIDDSSPYVK PETESSAFEL
     QSTESNAKYL GIDTTGERQA EARVVEYRSS DMPKMRTGTA VQSNAFGSMS VPRETRSGSS
     GESRPRAELP SKTAIASYGA LLQTPSYSVQ DKAYQPTLPM PSILDGQFWV FTDGPKLSLL
     RIESVALATR SDEIETKLAT GLIGQPLLMP VSVAADTDWS SLLDEHATLI RQLGLELTIR
     YQQLIIKKVP PYLRDCQLAR VIPEWLQSLR FEAPAPNALA IWLAEQSLTG FISAPDVWVA
     YCQLTEEKRQ QIASKAVSLP WQSWLEEQAI E