ID   MUTL_SHEPW              Reviewed;         620 AA.
AC   B8CIX3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=swp_0786;
OS   Shewanella piezotolerans (strain WP3 / JCM 13877).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=225849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WP3 / JCM 13877;
RX   PubMed=18398463; DOI=10.1371/journal.pone.0001937;
RA   Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L.,
RA   Bartlett D.H., Yu J., Hu S., Xiao X.;
RT   "Environmental adaptation: genomic analysis of the piezotolerant and
RT   psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans
RT   WP3.";
RL   PLoS ONE 3:E1937-E1937(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000472; ACJ27599.1; -; Genomic_DNA.
DR   RefSeq; WP_020910978.1; NC_011566.1.
DR   AlphaFoldDB; B8CIX3; -.
DR   SMR; B8CIX3; -.
DR   STRING; 225849.swp_0786; -.
DR   EnsemblBacteria; ACJ27599; ACJ27599; swp_0786.
DR   KEGG; swp:swp_0786; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000753; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..620
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192182"
FT   REGION          332..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  68513 MW;  B317187F1B6C0B77 CRC64;
     MAIEKLPPQL ANQIAAGEVV ERPASVIKEL VENSLDAGAT RVDIEIDKGG SKLIRIRDNG
     FGIPKQDLSL ALSRHATSKL KSLDDLEAIM SFGFRGEALA SISSVSRLTL TSRTETQAEA
     WQAKAEGTEM AVQILPAAHP VGTTIEAVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRRDIHFTLK HNGKSVRNYR PAMTEIQYLQ RLGQVCGKAF AETCLHISCS HNDLTLSGYL
     QAPGAASGYC ETQYFYVNGR LVKDRLVNHA VRQAFSEYAA GVSPGYVLML ELDPHQVDVN
     VHPAKHEVRF HQSRYVHDYI LQALQSAMAQ SSELGLEAQP EPTDESGAAF ESNSTNSNVS
     STSYSEPNTK PVAVNERPLT TTATSYNQGQ SSYRTPLRPA THRADVELPS QSSLEAYASL
     LSRSSAEPAS GKVVSNPHAS AVSDASVKMP AVLADKYWVI VEEDSIRLLS IADVIKETAR
     QQIQAKLAQG LVGQPLLMPV AVPVDDNWNE VIETREILLR KLGIELSIRL GQLIIKKVPP
     YLRDSQLAVL IPELLQWIRF EEPSDDALVH WLTTQASSRF TASAEAWLAF STLDSSAKSA
     LYNQSQELPW QQWMKESQSD