ID   MUTL_SHESA              Reviewed;         648 AA.
AC   A0KSR5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Shewana3_0595;
OS   Shewanella sp. (strain ANA-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=94122;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANA-3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D.,
RA   Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. ANA-3.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000469; ABK46834.1; -; Genomic_DNA.
DR   RefSeq; WP_011715787.1; NC_008577.1.
DR   AlphaFoldDB; A0KSR5; -.
DR   SMR; A0KSR5; -.
DR   STRING; 94122.Shewana3_0595; -.
DR   EnsemblBacteria; ABK46834; ABK46834; Shewana3_0595.
DR   KEGG; shn:Shewana3_0595; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002589; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..648
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076717"
FT   REGION          336..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..406
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  72088 MW;  A600E3159D37779D CRC64;
     MGIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIEIDKGG SKLIKIRDNG
     SGIPKDELAL ALSRHATSKL HSLDDLEAIL SFGFRGEALA SISSVSRLTL TSRTAEQTEA
     WQAYAEGADM AVKVMPAAHP VGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRGDIHFTLT HNGKIVRNCR PAMNEPQYLQ RLTQVAGRQF ADEALRVECQ HDDLRLSGYL
     QSPWSTVLTD THYFYVNGRL VRDRLVNHAV RQAFAQKAEV EQPGYVLMLD IDPHQVDVNV
     HPAKHEVRFH QSRYVHDYIL QALQSALEEA GELGFERPFE PSSPQIRDEA SLSETGAQTQ
     TEHHAFELQS PESKTHSTWN EASRVDTSRA ETSRESRIDS PLGERTRDIA SARPYAGVQS
     NAYGSMAVPR ESRSGSAGES RARAELPSKV AIASYGELLQ TPSYSVQDKP YQPVLAMPAI
     LNGQYWVLAQ GQNLSLLPIQ SVALATRSHE VETKLATGLI GQPLLMPVSI AADTDWPALL
     EEHETLIRQL GLELTIRYQQ LIIKKVPPYL RDSQLAKVIP EWLQSLRFEA PAPNALAVWL
     AEQSLTGFTS AADIWAAYCQ LTEEKRQQIA DKAVSLPWQS WLEEQASE