ID   MUTL_SHESH              Reviewed;         624 AA.
AC   A8FRD3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ssed_0795;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000821; ABV35406.1; -; Genomic_DNA.
DR   RefSeq; WP_012141142.1; NC_009831.1.
DR   AlphaFoldDB; A8FRD3; -.
DR   SMR; A8FRD3; -.
DR   STRING; 425104.Ssed_0795; -.
DR   EnsemblBacteria; ABV35406; ABV35406; Ssed_0795.
DR   KEGG; sse:Ssed_0795; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..624
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076718"
FT   REGION          340..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  69889 MW;  7C14F9C7DD1CCD1D CRC64;
     MTIQILPPQL ANQIAAGEVV ERPASVIKEL VENSLDAGAT RVDIEIEKGG SKLIKIHDNG
     SGISKEDLGL ALSRHATSKL SSLDDLDAIL SFGFRGEALA SISSVSRLTL TSRTADQVEA
     WQAYAEGSDM AVKVIPAAHP VGSTVEAVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRSDIHFTLK HNGKVVRNYR ATNTQDQYLQ RLAQISGKKF AEQAIEINCQ HDDLKLTGYV
     QSPFFETPAS DTQYFYVNGR LVRDRLVNHA VRQAFAEHET GEQASYVLML ELDPHQVDVN
     VHPAKHEVRF HQSRYVHDYI FQALQSALHQ VGRLAIDSDN KLDTDSHSQS HERGHSAYGV
     AEPSHSRHDY SHQTAPSTKA STETNRERFS SPISAVPSHT SDVQSRGGAT SSYRQQAELP
     SAAAIASYAE LLKTPDVDQG NRGNKELQAN VSMPPILAGQ YWVLTQEEQL LLLPVRIIST
     WLLQHEISNK LDSGLVSQPL LMPVSISMDE TWSDTLAERE LLLRKIGIEV TIRLGQLIIK
     KVPPYLRQSQ LVAVIPDLLQ WLRFEEPSNE ALASWLAKHD DKRFESAPDT WLAFSQLDDN
     VQDELIKKAK VLPWQSWLEE YPSD