ID   MUTL_SHESM              Reviewed;         644 AA.
AC   Q0HMP1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Shewmr4_0596;
OS   Shewanella sp. (strain MR-4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60480;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA   Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella sp. MR-4.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000446; ABI37676.1; -; Genomic_DNA.
DR   RefSeq; WP_011621397.1; NC_008321.1.
DR   AlphaFoldDB; Q0HMP1; -.
DR   SMR; Q0HMP1; -.
DR   KEGG; she:Shewmr4_0596; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..644
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076719"
FT   REGION          353..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  71875 MW;  960EE40FF50A1C42 CRC64;
     MGIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIEIDKGG SKLIKIRDNG
     SGIPKDELAL ALSRHATSKL HSLDDLEAIL SFGFRGEALA SISSVSRLTL TSRTAEQTEA
     WQAYAEGVDM AVKVMPAAHP VGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRGDIHFTLT HNGKTVRNYR PAMNEPQYLQ RLTQVAGRQF ADEALRVECQ HDDLRLSGYL
     QSPWSTVLTD THYFYVNGRL VRDRLVNHAV RQAFAQKAEV EQPGYVLMLD IDPHQVDVNV
     HPAKHEVRFH QSRYVHDYIL QALQSALEEA GELGFEHPFE PSSPQVRDEV SLSESGTQTQ
     TEHHAFELQS PESKTHSTWN EASRVDTSRV EISRDSQLTE RTRDIASARP YSGVQSNAYG
     SMAVPRESRS GPTGESRARA ELPSKAAIAS YGELLQTPSY SVQDKPYQPV LAMPAMLNGQ
     YWVLAQGQNL SLLPIQSVAL ATRSHEIETK LATGLIGQPL LMPVSIAADT DWPALLEEHE
     TLIRQLGLEL TIRYQQLIIK KVPPYLRDSQ LAKVIPEWLQ SLRFEAPAPN ALAVWLAEQS
     LTGFTSAADI WAAYSQLTEE KRQQIADKAV SLPWQSWLEE QAIE