ID   MUTL_SHESR              Reviewed;         644 AA.
AC   Q0HR40;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Shewmr7_3434;
OS   Shewanella sp. (strain MR-7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60481;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-7;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA   Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. MR-7.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000444; ABI44415.1; -; Genomic_DNA.
DR   RefSeq; WP_011627252.1; NC_008322.1.
DR   AlphaFoldDB; Q0HR40; -.
DR   SMR; Q0HR40; -.
DR   EnsemblBacteria; ABI44415; ABI44415; Shewmr7_3434.
DR   KEGG; shm:Shewmr7_3434; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..644
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076720"
FT   REGION          336..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..400
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  71881 MW;  DA5FA014CD185CEA CRC64;
     MGIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIEIDKGG SKLIKIRDNG
     SGIPKDELAL ALSRHATSKL HSLDDLEAIL SFGFRGEALA SISSVSRLTL TSRTAEQTEA
     WQAYAEGVDM AVKVMPAAHP VGSTIEVVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VRGDIHFTLT HNGKTVRNYR PAMNEPQYLQ RLTQVAGRQF ADEALRVECQ HDDLRLSGYL
     QSPWSTVLTD THYFYVNGRL VRDRLVNHAV RQAFAQKAEV EQPGYVLMLD IDPHQVDVNV
     HPAKHEVRFH QSRYVHDYIL QALQSALEEA GELGFERPFE PSSPQVRDEV SLSESGAQTQ
     TEHHAFELQS PESKTHSTWD EASRVDTSRA EISRDSSLGE RTRDIASTRP YAGVQSNAYG
     SMAVPRESRS GSTGESRARA ELPSKVAIAS YGELLQTPSY NVQDKPYQPV LAMPAILNGQ
     YWVLAQEQNL SLLPIQSVAL ATRSHEIETK LATGLIGQPL LMPVSIAADT DWPALLEEHE
     TLIRQLGLEL TIRYQQLIIK KVPPYLRDSQ LAKVIPEWLQ SLRFEAPAPN ALAVWLAEQS
     LTGFTSAADI WAAYCQLTEE KRQQIADKAV SLPWQSWLEE QAIE