ID   MUTL_SHEWM              Reviewed;         614 AA.
AC   B1KHV0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Swoo_4172;
OS   Shewanella woodyi (strain ATCC 51908 / MS32).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=392500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51908 / MS32;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella woodyi ATCC 51908.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000961; ACA88428.1; -; Genomic_DNA.
DR   RefSeq; WP_012326757.1; NC_010506.1.
DR   AlphaFoldDB; B1KHV0; -.
DR   SMR; B1KHV0; -.
DR   STRING; 392500.Swoo_4172; -.
DR   EnsemblBacteria; ACA88428; ACA88428; Swoo_4172.
DR   KEGG; swd:Swoo_4172; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; FTHIDEW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002168; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..614
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096687"
FT   REGION          355..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  68598 MW;  AB093712A55BD2D4 CRC64;
     MTIQILSPQL ANQIAAGEVV ERPASVIKEL VENSLDAGAT RVDIEIDKGG SKLIKIQDNG
     SGIPKSELNL ALSRHATSKL STLDDLDAIL SFGFRGEALA SISSVSRLTL TSRTAEQTEA
     WQAYAEGSDM AVKVIPAAHP VGTTIEAVDL FFNTPARRRF LKSDKTEFTH IDEWLKRIAL
     VKPEIHFTLK HNGKQVRNYR PANNQDQYLM RLAQICGKNF AEQAIEIDCQ HEGLTLSGYI
     QSPFFTSPAS DTQFFYVNGR LIRDRLVNHA VRQAFSEHGT GELASYVLML EIAPHQVDVN
     VHPAKHEVRF HQSRYVHDYI LQALQSALMQ VARASISLPE EKLVEFVEDD WHSKPLSTGR
     VSEADPSNYA TQSKFDEKPR ESGSQGQSSS ISAPSSYSRG GEYSARSQPE LPSASEIASY
     TQLLKTPQTA QASKLVNSDL KTPMPPVLAG QYWVYAGDEL SLLPIDIVAK WLVKRDILAK
     IDNGLVSQPL LMPVSIKVDE DWLNTIDERE QLLRQLGIEI TIRLGQLIIK KVPPYLRQSQ
     LVTVIPELLQ WVRFEEPTHE ALALWLAKQD DGKFESAVAT WSAFSQLDDE IQQELAQKAK
     VLPWQSWLEE QLSD