ID   MUTL_SINMW              Reviewed;         605 AA.
AC   A6U6K5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Smed_0428;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000738; ABR59285.1; -; Genomic_DNA.
DR   RefSeq; WP_011974632.1; NC_009636.1.
DR   RefSeq; YP_001326120.1; NC_009636.1.
DR   AlphaFoldDB; A6U6K5; -.
DR   SMR; A6U6K5; -.
DR   STRING; 366394.Smed_0428; -.
DR   PRIDE; A6U6K5; -.
DR   EnsemblBacteria; ABR59285; ABR59285; Smed_0428.
DR   GeneID; 61609702; -.
DR   KEGG; smd:Smed_0428; -.
DR   PATRIC; fig|366394.8.peg.3510; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..605
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010081"
SQ   SEQUENCE   605 AA;  65075 MW;  3CACA31E74F09AE8 CRC64;
     MAIKQLSETL INQIAAGEVI ERPASAAKEL IENALDAGAT RIEIATAGGG KTLLRVTDNG
     LGMSPADLEL AIRRHCTSKL DGSLADIRTL GFRGEALPSI GSVARLSITT RTAEAREGAT
     ITITGGRSDP VRPSAAVVGT VVEVRELFFA TPARLKFMKS ERAETAAISE VVRRMAIAFP
     KVRFVLSGSD RSALEFPATG DDRLARMAQV LGRDFRDNAI EIDAEREGAR LTGFAGVPTF
     NRGNSLQQYA FVNGRPVQDK LIMSAIRAAY AETVPQGRYP VAVLSLTIDP ALVDVNVHPA
     KSDVRFRDPG LIRGLIIGAI REALMREGDR AATTGAQGLM RAFRPEFHRG DQQRPQEPWT
     AATSPYRPFS PGGAARGFAE TPQAAFSDFA QPSARNAAVP VDSIQAADGQ AASFPLGAAR
     AQLHENYIVA QTDDGLVIVD QHAAHERLVF ETMRTALHAR PVPAQALLIP EIVDLPEEDC
     DRLVAHAGEF TRLGLAIERF GPAAIAVRET PAMLGEMDAA GLVRQLADEL AEWDTADGLA
     GRLEYLAATM ACHGSVRSGR RLRTEEMNAL LRRMEATPGS GQCNHGRPTY IELKLADIER
     LFGRS