ID   MUTL_SOLUE              Reviewed;         660 AA.
AC   Q01QW7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Acid_7040;
OS   Solibacter usitatus (strain Ellin6076).
OC   Bacteria; Acidobacteria; Bryobacterales; Solibacteraceae;
OC   Candidatus Solibacter.
OX   NCBI_TaxID=234267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin6076;
RX   PubMed=19201974; DOI=10.1128/aem.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000473; ABJ87953.1; -; Genomic_DNA.
DR   RefSeq; WP_011688673.1; NC_008536.1.
DR   AlphaFoldDB; Q01QW7; -.
DR   SMR; Q01QW7; -.
DR   STRING; 234267.Acid_7040; -.
DR   EnsemblBacteria; ABJ87953; ABJ87953; Acid_7040.
DR   KEGG; sus:Acid_7040; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..660
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076721"
SQ   SEQUENCE   660 AA;  73398 MW;  96888B57D3F44FAE CRC64;
     MGRIRILPDQ VANKIAAGEV VERPASVVKE LLENSLDAGA TEVRVEVEAG GRRLIRIVDD
     GFGMLRDDAL LAFERHATSK LRDVKDLLSI ATLGFRGEAL PSIASVSRLL LETRSMEEPT
     GTRIEIAGGK MLRCEEAALG GGTVITVRDL FYNVPARRKF LRTEPTELAH IASLVTHYSL
     AHPDKSFRLS TGPTELLGVT PVASMKERVY QVFGSQILDE LVEIGVRERD LFLPPPSVPP
     SQAIAEYRST EPEDPPFRRF RLTGFFSRPQ IQKSNRNSIY IFVNGRLIRD RLVLHALSSA
     YHNLMPASAY PFALLFLECD AEEVDVNVHP SKTEVRFRHG SFLHDFIRDS IRERLMESRP
     APTFSPVPMA APPAQQGAQL PYSEFSQMLE NEQQAASEMA EPAIAGEPAM PEFNLRATAP
     PTPRLDFSAP PIEVAPGPPP SGKLSRRLDM HGEFPLEAIP APEMSLSALS DLRPLGQIHE
     SFIIAAGRDG LWIIDQHVAH ERILFEQVLK QRAAGRVETQ RLLMPMILQL SAEQQIDYAR
     IADELHASGF ETEPFGNRTI AVKAAPAAVG PQDLERILFE ILEIAENEMR TNSLDDLRRN
     ICASIACRAA IKINMRLDLA KMEWLLRALA ATDCPMSCPH GRPIAMHYST REILKAFHRI