ID   MUTL_STAA8              Reviewed;         669 AA.
AC   Q93T05; Q2FYZ8;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=SAOUHSC_01273;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12161395; DOI=10.1093/jac/dkf118;
RA   O'Neill A.J., Chopra I.;
RT   "Insertional inactivation of mutS in Staphylococcus aureus reveals
RT   potential for elevated mutation frequencies, although the prevalence of
RT   mutators in clinical isolates is low.";
RL   J. Antimicrob. Chemother. 50:161-169(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AF378369; AAK56306.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD30374.1; -; Genomic_DNA.
DR   RefSeq; WP_000516261.1; NZ_LS483365.1.
DR   RefSeq; YP_499806.1; NC_007795.1.
DR   AlphaFoldDB; Q93T05; -.
DR   SMR; Q93T05; -.
DR   STRING; 1280.SAXN108_1301; -.
DR   EnsemblBacteria; ABD30374; ABD30374; SAOUHSC_01273.
DR   GeneID; 3919926; -.
DR   KEGG; sao:SAOUHSC_01273; -.
DR   PATRIC; fig|93061.5.peg.1167; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   PRO; PR:Q93T05; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..669
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177973"
FT   REGION          356..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        385
FT                   /note="Q -> R (in Ref. 1; AAK56306)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        417
FT                   /note="N -> D (in Ref. 1; AAK56306)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   669 AA;  76855 MW;  0093F0C6768D2930 CRC64;
     MGKIKELQTS LANKIAAGEV VERPSSVVKE LLENAIDAGA TEISIEVEES GVQSIRVVDN
     GSGIEAEDLG LVFHRHATSK LDQDEDLFHI RTLGFRGEAL ASISSVAKVT LKTCTDNANG
     NEIYVENGEI LNHKPAKAKK GTDILVESLF YNTPARLKYI KSLYTELGKI TDIVNRMAMS
     HPDIRIALIS DGKTMLSTNG SGRTNEVMAE IYGMKVARDL VHISGDTSDY HIEGFVAKPE
     HSRSNKHYIS IFINGRYIKN FMLNKAILEG YHTLLTIGRF PICYINIEMD PILVDVNVHP
     TKLEVRLSKE EQLYQLIVSK IQEAFKDRIL IPKNNLDYVP KKNKVLHSFE QQKIEFEQRQ
     NTENNQEKTF SSEESNSKPF MEENQNDEIV IKEDSYNPFV TKTSESLIAD DESSGYNNTR
     EKDEDYFKKQ QEILQEMDQT FDSNDGTTVQ NYENKASDDY YDVNDIKGTK SKDPKRRIPY
     MEIVGQVHGT YIIAQNEFGM YMIDQHAAQE RIKYEYFRDK IGEVTNEVQD LLIPLTFHFS
     KDEQLVIDQY KNELQQVGIM LEHFGGHDYI VSSYPVWFPK DEVEEIIKDM IELILEEKKV
     DIKKLREDVA IMMSCKKSIK ANHYLQKHEM SDLIDQLREA EDPFTCPHGR PIIINFSKYE
     LEKLFKRVM