ID   MUTL_STAAE              Reviewed;         669 AA.
AC   A6QGJ5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=NWMN_1205;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP009351; BAF67477.1; -; Genomic_DNA.
DR   RefSeq; WP_000516261.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QGJ5; -.
DR   SMR; A6QGJ5; -.
DR   EnsemblBacteria; BAF67477; BAF67477; NWMN_1205.
DR   KEGG; sae:NWMN_1205; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..669
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071510"
FT   REGION          356..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  76855 MW;  0093F0C6768D2930 CRC64;
     MGKIKELQTS LANKIAAGEV VERPSSVVKE LLENAIDAGA TEISIEVEES GVQSIRVVDN
     GSGIEAEDLG LVFHRHATSK LDQDEDLFHI RTLGFRGEAL ASISSVAKVT LKTCTDNANG
     NEIYVENGEI LNHKPAKAKK GTDILVESLF YNTPARLKYI KSLYTELGKI TDIVNRMAMS
     HPDIRIALIS DGKTMLSTNG SGRTNEVMAE IYGMKVARDL VHISGDTSDY HIEGFVAKPE
     HSRSNKHYIS IFINGRYIKN FMLNKAILEG YHTLLTIGRF PICYINIEMD PILVDVNVHP
     TKLEVRLSKE EQLYQLIVSK IQEAFKDRIL IPKNNLDYVP KKNKVLHSFE QQKIEFEQRQ
     NTENNQEKTF SSEESNSKPF MEENQNDEIV IKEDSYNPFV TKTSESLIAD DESSGYNNTR
     EKDEDYFKKQ QEILQEMDQT FDSNDGTTVQ NYENKASDDY YDVNDIKGTK SKDPKRRIPY
     MEIVGQVHGT YIIAQNEFGM YMIDQHAAQE RIKYEYFRDK IGEVTNEVQD LLIPLTFHFS
     KDEQLVIDQY KNELQQVGIM LEHFGGHDYI VSSYPVWFPK DEVEEIIKDM IELILEEKKV
     DIKKLREDVA IMMSCKKSIK ANHYLQKHEM SDLIDQLREA EDPFTCPHGR PIIINFSKYE
     LEKLFKRVM