ID   MUTL_STACT              Reviewed;         646 AA.
AC   B9DPC0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sca_0946;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM295250; CAL27854.1; -; Genomic_DNA.
DR   RefSeq; WP_015900195.1; NC_012121.1.
DR   AlphaFoldDB; B9DPC0; -.
DR   SMR; B9DPC0; -.
DR   STRING; 396513.SCA_0946; -.
DR   GeneID; 60545361; -.
DR   KEGG; sca:SCA_0946; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; SCAR396513:SCA_RS04760-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..646
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000123215"
FT   REGION          356..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..452
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  73744 MW;  741591771C4DDA59 CRC64;
     MGNIKELQTS LANKIAAGEV VERPGSVVKE LLENALDAKA TEINIEIKQS GIESIRVVDN
     GTGIEEDDLK LVFHRHATSK LHEDSDLFHI RTLGFRGEAL ASISSVAKVT LRTCTDGQSG
     HEIYAEDGAI LEQKPAKAKK GTDILVESLF YNTPARLKYV KSLYTELGKI TDIVNRMAMS
     HPNVRFTLTS DDKVLIKTNG SGRTNEVMAE IYGMKVAKDL VHITGDTSDY HLEGYVAKPE
     HSRSNRHYIS IFINGRYIKN FVLNKAIVEG YHTLLTIGRY PICYINIEMD PILVDVNVHP
     TKLEVRLSKE EQLYQLIVQK IQEAFKDKIL IPHNDENKLY KKNKVLDVFE QQKLDFENRT
     ASNPPAEKPD EETDRVNENS DTQAFQTNEQ TSENGSDASY QAGQRAVLQD LEGNTKNSEG
     LFDSEATSNE AASAEIESSE DDVRETEHAK PHRRVPYMEV VGQVHGTYII AQNETGMFMI
     DQHAAQERIK YEYFRDKIGE VTNEVQNLLI PMTFHFSKDE QMIINQYKDE LDKVGVHLEP
     FGSHDYIVNS YPVWFPKEEA QEIIQDMVEY VLEHRKVDIK KIREEAAIMM SCKKSIKANH
     YLRNHEMADL IDQLREMEDP FTCPHGRPII ISFSNYELER LFKRIM