ID   MUTL_STRA3              Reviewed;         657 AA.
AC   Q8E2R5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=gbs2052;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AL766856; CAD47711.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8E2R5; -.
DR   SMR; Q8E2R5; -.
DR   STRING; 211110.gbs2052; -.
DR   EnsemblBacteria; CAD47711; CAD47711; CAD47711.
DR   KEGG; san:mutL; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..657
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010088"
SQ   SEQUENCE   657 AA;  73759 MW;  C51CD9BBF77729DD CRC64;
     MSKIIELPDI LANQIAAGEV VERPSSVVKE LVENAIDAGS SQITIEVEES GLKKIQITDN
     GEGMTSEDAV LSLRRHATSK IKSQSDLFRI RTLGFRGEAL PSIASISLMT IKTATEQGKQ
     GTLLVAKGGN IEKQEVVSSP RGTKILVENL FFNTPARLKY MKSLQSELAH IIDIVNRLSL
     AHPEVAFTLI NDGKEMTKTS GTGDLRQAIA GIYGLNTAKK MIEISNADLD FEISGYVSLP
     ELTRANRNYI TLLINGRYIK NFLLNRSILD GYGSKLMVGR FPIAVIDIQI DPYLADVNVH
     PTKQEVRISK ERELMSLIST AISESLKQYD LIPDALENLA KTSTRSVDKP IQTSFSLKQP
     GLYYDRAKND FFIGADTVSE PIANFTNLDK SDGSVDNDVK NSVNQGATQS PNIKYASRDQ
     ADSENFIHSQ DYLSSKQSLN KLVEKLDSEE SSTFPELEFF GQMHGTYLFA QGNGGLYIID
     QHAAQERVKY EYYREKIGEV DNSLQQLLVP FLFEFSSSDF LQLQEKMSLL QDVGIFLEPY
     GNNTFILREH PIWMKEEEVE SGIYEMCDML LLTNEVSVKK YRAELAIMMS CKRSIKANHT
     LDDYSARHLL DQLAQCKNPY NCPHGRPVLV NFTKADMEKM FKRIQENHTS LRDLGKY