ID   MUTL_STREM              Reviewed;         660 AA.
AC   B4U0J7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Sez_1882;
OS   Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=552526;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGCS10565;
RX   PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA   Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R.,
RA   Musser J.M.;
RT   "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain
RT   causing epidemic nephritis: new information about an old disease.";
RL   PLoS ONE 3:E3026-E3026(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001129; ACG63206.1; -; Genomic_DNA.
DR   RefSeq; WP_012516450.1; NC_011134.1.
DR   AlphaFoldDB; B4U0J7; -.
DR   SMR; B4U0J7; -.
DR   EnsemblBacteria; ACG63206; ACG63206; Sez_1882.
DR   KEGG; sez:Sez_1882; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001873; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..660
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096689"
SQ   SEQUENCE   660 AA;  74127 MW;  BE7D2820DB551476 CRC64;
     MTTIIELPEV LANQIAAGEV IERPASVVKE LVENAIDAKS SQITVEIEES GLKMMQITDN
     GEGMSHEDLP LSLRRHATSK IKSQSDLFRI RTLGFRGEAL PSVASISKLT IKTATAEAEH
     GSILVASGGK IEQLEAVSTP VGTKIKVENL FYNTPARLKY MKSLQAELAH VVDVVNRLSL
     AHPEIAFTLI SDGKQLTQTS GTGDLRQALA GIYGLNTAKK MIDISSADLD FEVGGFVSLP
     ELTRANRNYI TILINGRYIK NFLLNRAILD GYGSKLMVGR FPIAVIDIQI DPYLADVNVH
     PTKQEIRISK ERELMALIST AISESLREQD LIPDALENLA RSSTRSFSKP EQTSLPLQPS
     QLYYDPQKND FFTKETVVSE DSPQGFNHEV LIDSDVKQVD NLQVAKTESE AAAPSVKYAS
     RPDPMLSDGE HPGLDVHNKQ KLSQMLDRLE NEEQSVFPEL DYFGQMHGTY LFAQGRDGLF
     IIDQHAAQER VKYEYYRDKI GEVDNSLQQL LVPYLFEFSG SDFINLQEKM SLLNEVGIYL
     EPYGNHTFIL REHPIWMKEA EIESGVYEMC DMLLLTNEVS IKTYRAELAI MMSCKRSIKA
     NHSLDDYSAR QLLLQLAQCK NPYNCPHGRP VLINFSKADM EKMFRRIQEN HTSLRELGKY