ID   MUTL_STRGC              Reviewed;         647 AA.
AC   A8AZU1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SGO_2053;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000725; ABV10687.1; -; Genomic_DNA.
DR   RefSeq; WP_012131022.1; NC_009785.1.
DR   AlphaFoldDB; A8AZU1; -.
DR   SMR; A8AZU1; -.
DR   STRING; 467705.SGO_2053; -.
DR   EnsemblBacteria; ABV10687; ABV10687; SGO_2053.
DR   KEGG; sgo:SGO_2053; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..647
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076724"
FT   REGION          390..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  73305 MW;  18E50CD7170D6261 CRC64;
     MSKIIELPEI LANQIAAGEV IERPSSVVKE LVENSIDAGA SQITIEIEEA GLKTIQVTDN
     GEGIDHEDVP LALRRHATSK IKKQADLFRI RTLGFRGEAI PSIASVSRFT IETATENGQH
     GTLLVAQGGE IEEHEPTSSP VGTKIKIEDL FFNTPARLKY MKSQQAELSH IVDVINRLSL
     AHPEVAFTLI SDGREMTRTA GSGNLRQAIA GIYGLATAKK MVEISASDLD FEVSGYVSLP
     ELTRANRNYI TILINGRYIK NFLLNRAILD GYGSKLMVGR FPLAVINIQI DPYLADVNVH
     PTKQEVRISK ERELMALISQ AIAASLKEQD LIPDALENLA KSTVKRATKP EQTSLPLKEN
     RLYYDKERND FFLKPQVAEQ QISFEESAEP IHEATDEKAE PQPTSVKFAE RKPASYDQLD
     HPELNQASLE RAVDKLEQEE KSSFPELEYF GQMHGTYLFA QGKGGLYIID QHAAQERVKY
     EYYREKIGDV DNSQQQLLVP YIFEFPADDM LRIKQRMKLL EDAGIFLEEY GANQFILREH
     PIWFKEEEIE DGIYEMCDML LLTKEVSIKK YRAELAIMMS CKRSIKANHG LDDYSARDLL
     FQLSQCDNPY NCPHGRPVLV NFTKSDMEKM FRRIQENHTS LRELGKY