ID   MUTL_STRMU              Reviewed;         651 AA.
AC   Q8DRX0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SMU_2089;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE014133; AAN59684.1; -; Genomic_DNA.
DR   RefSeq; NP_722378.1; NC_004350.2.
DR   RefSeq; WP_002262396.1; NC_004350.2.
DR   AlphaFoldDB; Q8DRX0; -.
DR   SMR; Q8DRX0; -.
DR   STRING; 210007.SMU_2089; -.
DR   PRIDE; Q8DRX0; -.
DR   EnsemblBacteria; AAN59684; AAN59684; SMU_2089.
DR   KEGG; smu:SMU_2089; -.
DR   PATRIC; fig|210007.7.peg.1859; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q8DRX0; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..651
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010089"
SQ   SEQUENCE   651 AA;  73811 MW;  D1E7245BF076FA67 CRC64;
     MSKIIELPEV LANQIAAGEV IERPASVVKE LVENAIDADS SQITIEIEES GLKKIQVTDN
     GQGIEQADVI MSLRRHATSK IKKQSDLFRI RTLGFRGEAL PSIASISRLT LKTATKGEIY
     GTLLIANGGK IEKEEAISTP IGTKVSVENL FFNTPARLKY MKSLQAELAH IIDVINRLSL
     AHPEIAFTLI NDGRELTKTA GKGDLRQALA GIYGVTIAKK MVEISNADLD FEVSGYISLP
     ELTRANRNYI TILINGRYIK NFLLNRAILD GYGSKLMVGR FPIAVIDIQI DPYLADVNVH
     PTKQEVRISK EKELMNLVSS AIADSLREQE LIPDALENLA KTSTNKKQKF EQTQLPLKQS
     NLYYDKTQND FFLKETTVSE ASSEFTVVDK AVNITDNVSG HSSVKYAQRQ MRTCENKEHP
     SLTMTDKQQK RQLSRIVESL ENEEKSTFPE LEYFGQMHGT YLFAQGEGGL YIIDQHAAQE
     RVKYEYYRDK IGEVDNSLQQ LLVPYLFEFP ANDFMTLQEK MSILNEVGIH LENYGENTFI
     LREHPIWLQE KEIESAVYEM CDMLLLTNEV SIKKYRAELA IMMSCKRSIK ANHTLDDYSA
     RNLLIQLSQC KNPYNCPHGR PVLVNFTKAD MEKMFRRIQE NHTSLRELGK Y