ID   MUTL_STRP1              Reviewed;         660 AA.
AC   Q99XN7; Q48W53;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=SPy_2121, M5005_Spy1804;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE004092; AAK34766.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52422.1; -; Genomic_DNA.
DR   RefSeq; NP_270045.1; NC_002737.2.
DR   AlphaFoldDB; Q99XN7; -.
DR   SMR; Q99XN7; -.
DR   STRING; 1314.HKU360_01918; -.
DR   PaxDb; Q99XN7; -.
DR   EnsemblBacteria; AAK34766; AAK34766; SPy_2121.
DR   KEGG; spy:SPy_2121; -.
DR   KEGG; spz:M5005_Spy1804; -.
DR   PATRIC; fig|160490.10.peg.1838; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..660
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177979"
SQ   SEQUENCE   660 AA;  74286 MW;  BCE1D37EC3F00196 CRC64;
     MTNIIELPEV LANQIAAGEV VERPASVVKE LVENAIDAKS SQITVEIEES GLKMIQVTDN
     GEGMSHEDLP LSLRRHATSK IKSQSDLFRI RTLGFRGEAL PSVASISKIT IKTATKEVTH
     GSLLIATGGE IETLEAISTP TGTKIKVENL FYNTPARLKY MKSLQAELAH IVDVVNRLSL
     AHPEVAFTLI SDGRQLTQTS GTGDLRQAIA GIYGLNTTKK MLAISNADLD FEVSGYVSLP
     ELTRANRNYM TILVNGRYIK NFLLNRAILD GYGSKLMVGR FPIVVIDIQI DPYLADVNVH
     PTKQEVRISK ERELMALIST AISESLKEQD LIPDALENLA KSSTRHFSKP EQTQLPLQSR
     GLYYDPQKND FFVKESAVSE KIPETDFYSG AVDNSVKVEK VELLPHSEEV IGPSSVKHAS
     RPQNTFTETD HPNLDLKNRQ KLSQMLTRLE NEGQSVFPEL DYFGQMHGTY LFAQGKDGLF
     IIDQHAAQER VKYEYYRDKI GEVDSSLQQL LVPYLFEFSG SDFINLQEKM ALLNEVGIFL
     EVYGHNTFIL REHPIWMKEE EIASGVYEMC DMLLLTNEVS IKTYRAELAI MMSCKRSIKA
     NHSLDDYSAR NLLLQLAQCQ NPYNCPHGRP VLINFSKADM EKMFRRIQEN HTSLRELGKY