ID   MUTL_STRP2              Reviewed;         649 AA.
AC   Q04MR4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SPD_0165;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000410; ABJ54692.1; -; Genomic_DNA.
DR   RefSeq; WP_000018169.1; NC_008533.2.
DR   AlphaFoldDB; Q04MR4; -.
DR   SMR; Q04MR4; -.
DR   STRING; 373153.SPD_0165; -.
DR   EnsemblBacteria; ABJ54692; ABJ54692; SPD_0165.
DR   GeneID; 60232517; -.
DR   KEGG; spd:SPD_0165; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; SPNE373153:G1G6V-184-MON; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..649
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010090"
SQ   SEQUENCE   649 AA;  73435 MW;  465C89A3CA7C7E65 CRC64;
     MSHIIELPEM LANQIAAGEV IERPASVVKE LVENAIDAGS SQIIIEIEEA GLKKVQITDN
     GHGIAHDEVE LALRRHATSK IKNQADLFRI RTLGFRGEAL PSIASVSVLT LLTAVDGASH
     GTKLVARGGE VEEVIPATSP VGTKVCVEDL FFNTPARLKY MKSQQAELSH IIDIVNRLGL
     AHPEISFSLI SDGKEMTRTA GTGQLRQAIA GIYGLVSAKK MIEIENSDLD FEISGFVSLP
     ELTRANRNYI SLFINGRYIK NFLLNRAILD GFGSKLMVGR FPLAVIHIHI DPYLADVNVH
     PTKQEVRISK EKELMTLVSE AIANSLKEQT LIPDALENLA KSTVRNREKV EQTILPLKEN
     TLYYEKTEPS RPSQTEVADY QVELTDEGQD LTLFAKETLD RLTKPAKLHF AERKPANYDQ
     LDHPELDLAS IDKAYDKLER EEASSFPELE FFGQMHGTYL FAQGRDGLYI IDQHAAQERV
     KYEEYRESIG NVDQSQQQLL VPYIFEFPAD DALRLKERMP LLEEVGVFLA EYGENQFILR
     EHPIWMAEEE IESGIYEMCD MLLLTKEVSI KKYRAELAIM MSCKRSIKAN HRIDDHSARQ
     LLYQLSQCDN PYNCPHGRPV LVHFTKSDME KMFRRIQENH TSLRELGKY