ID   MUTL_STRPB              Reviewed;         660 AA.
AC   Q1J9C2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=MGAS2096_Spy1837;
OS   Streptococcus pyogenes serotype M12 (strain MGAS2096).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370553;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS2096;
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA   Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in the
RT   human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000261; ABF36889.1; -; Genomic_DNA.
DR   RefSeq; WP_002991363.1; NC_008023.1.
DR   AlphaFoldDB; Q1J9C2; -.
DR   SMR; Q1J9C2; -.
DR   KEGG; spj:MGAS2096_Spy1837; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..660
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010091"
SQ   SEQUENCE   660 AA;  74357 MW;  8FE0E95410C31399 CRC64;
     MTNIIELPEV LANQIAAGEV VERPASVVKE LVENAIDAKS SQITVEIEES GLKMIQVTDN
     GEGMSHEDLP LSLRRHATSK IKSQSDLFRI RTLGFRGEAL PSVASISKIT IKTATKEVTH
     GSLLIATGGE IETLEAISTP TGTKIKVENL FYNTPARLKY MKSLQAELAH IVDVVNRLSL
     AHPEVAFTLI SDGRQLTQTS GTGDLRQAIA GIYGLNTTKK MLVISNADLD FEVSGYVSLP
     ELTRANRNYM TILVNGRYIK NFLLNRAILD GYGSKLMVGR FPIVVIDIQI DPYLADVNVH
     PTKQEVRISK ERELMALIST AISESLKEQD LIPDALENLA KSSTRHFSKP EQTQLPLQSR
     GLYYDPQKND FFVKESAVSE KIPETDFYSG AVDNSVKVEK AELLPHSEEV IGPSSVKHAS
     RPQNTFTETD HPNLDLKNRQ KLSQMLNRLE NEEQSVFPEL DYFGQMHGTY LFAQGKDGLF
     IIDQHAAQER VKYEYYRDKI GDVDSSLQQL LVPYLFEFSG SDFINLQEKM ALLNEVGIFL
     EVYGHNTFIL REHPIWMKEE EIASGVYEMC DMLLLTNEVS IKTYRAELAI MMSCKRSIKA
     NHSLDDYSAR NLLLQLAQCQ NPYNCPHGRP VLINFSKADM EKMFRRIQEN HTSLRELGKY