ID   MUTL_STRSV              Reviewed;         647 AA.
AC   A3CR14;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SSA_2257;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000387; ABN45619.1; -; Genomic_DNA.
DR   RefSeq; WP_011837650.1; NC_009009.1.
DR   RefSeq; YP_001036169.1; NC_009009.1.
DR   AlphaFoldDB; A3CR14; -.
DR   SMR; A3CR14; -.
DR   STRING; 388919.SSA_2257; -.
DR   EnsemblBacteria; ABN45619; ABN45619; SSA_2257.
DR   KEGG; ssa:SSA_2257; -.
DR   PATRIC; fig|388919.9.peg.2140; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..647
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010094"
FT   REGION          387..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  73224 MW;  F1C220DE2AD20829 CRC64;
     MSKIIELPEI LANQIAAGEV IERPSSVVKE LVENSIDAGA SQITIEIEEA GLKSIQVTDN
     GEGIDHEDVP LALRRHATSK IKKQADLFRI RTLGFRGEAI PSIASVSRFT IETATEAGRH
     GTLLVAQGGE IEEHVPTSSP VGTKIKIEDL FFNTPARLKY MKSQQAELSH IVDVINRLSL
     AHPEVAFTLI SDGREMTRTA GSGNLRQAIA GIYGLATAKK MVEISASDLD FEVSGYVSLP
     ELTRANRNYI TILINGRYIK NFLLNRAILD GYGSKLMVGR FPLAVINIQI DPYLADVNVH
     PTKQEVRISK ERELMALISQ AIATSLKEQD LIPDALENLA KSTVKRASKP EQTSLPLKEN
     RLYYDKKQND FFLKPQVAEQ QLSFEESAKP VHEATDEKAE PQSTSVKFAE RKPVSYDQLD
     HPELDQASLE RAVDKLEQEE KSSFPELEYF GQMHGTYLFA QGKGGLYIID QHAAQERVKY
     EYYREKIGDV DNSQQQLLVP YIFEFPADDM LRIKQRMELL EDAGIFLEEY GANQFILREH
     PIWFKEEEIE AGIYEMCDML LLTKEVSIKK YRAELAIMMS CKRSIKANHS LDDYSARDLL
     FQLSQCDNPY NCPHGRPVLV NFTKSDMEKM FRRIQENHTS LRELGKY