MUTL_STRT1
ID MUTL_STRT1 Reviewed; 647 AA.
AC Q5M1Y6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=str0054;
OS Streptococcus thermophilus (strain CNRZ 1066).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=299768;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNRZ 1066;
RX PubMed=15543133; DOI=10.1038/nbt1034;
RA Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT "Complete sequence and comparative genome analysis of the dairy bacterium
RT Streptococcus thermophilus.";
RL Nat. Biotechnol. 22:1554-1558(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000024; AAV61671.1; -; Genomic_DNA.
DR RefSeq; WP_011225282.1; NC_006449.1.
DR AlphaFoldDB; Q5M1Y6; -.
DR SMR; Q5M1Y6; -.
DR GeneID; 66897972; -.
DR KEGG; stc:str0054; -.
DR HOGENOM; CLU_004131_5_1_9; -.
DR OMA; AHERIMY; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..647
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010095"
FT REGION 393..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 72505 MW; 416AF7B1E7F0AF85 CRC64;
MPKIIELPEV LANQIAAGEV VERPASVVKE LVENAIDAGS TQITIEVEES GLSKIQITDN
GEGMAQADVA MSLRRHATSK IKNQGDLFRI RTLGFRGEAL PSIASISHLT IVTAADGEVY
GTKLVAKGGE IESQDPISTP VGTKITVENL FYNTPARLKY MKSLQAELAH IVDVVNRLSL
AHPEVAFTLL NDGRQLTQTS GTGDLRQAIA GIYGLTTAKK MVEISNSDLD FEVSGYVSLP
ELTRANRNYI TILINGRYIK NFLLNRAIFD GYGSKLMVGR FPIAVIDIQI DPYLADVNVH
PTKQEVRISK EKELMALIKS AIAQSLREQD LIPDALENLA KSSTRGATRS VQTSLPLKQT
NLYYDSSRND FFVTPETVQE DIKPLVSKSE SSVSLVANKQ QPTVKQAKRS ADDSDSEHGK
LDYKNKSKLK RMLENLTNEE TSTFPELEFF GQMHGTYLFA QGQGGLYIID QHAAQERVKY
EYYREKIGVV DSSLQQLLVP YLFEFSGSDY ISLQEKMPLL NQVCIYLEPY GNNTFILREH
PIWMKEEEIE SAVYEMCDML LLTNEVSVKT YRAELAIMMS CKRSIKANHA LDDYSARDLL
VQLAQCKNPY NCPHGRPVLV NFTKSDMEKM FRRIQENHTS LRDLGKY