ID   MUTL_SYMTH              Reviewed;         635 AA.
AC   Q67NL0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=STH1748;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP006840; BAD40733.1; -; Genomic_DNA.
DR   RefSeq; WP_011195876.1; NC_006177.1.
DR   AlphaFoldDB; Q67NL0; -.
DR   SMR; Q67NL0; -.
DR   STRING; 292459.STH1748; -.
DR   EnsemblBacteria; BAD40733; BAD40733; STH1748.
DR   KEGG; sth:STH1748; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..635
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096694"
FT   REGION          352..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  68299 MW;  8DC896BB5A9FF85B CRC64;
     MARIRLLDER TANQIAAGEV VERPASVVKE LVENALDAQA KRIVVEVSGG GRELVRVTDD
     GIGMVPEDAR LALQRHATSK IRTAEDLNAI TTLGFRGEAL PSIAAVSQFE LITRPHDQLA
     GYRILAEGGQ IVAEGEHGCP AGTRVTVRDL FFNVPARLKY LKTNATELAQ IGDILTRLAL
     ANPEVAFRFQ SGQAQVFATP GTGDLTAAVA ALLGREMAKE LLPVDYRNDA ARVHGFVGRP
     TIARAGRSHQ YFFVNRRAVR TIAARYALEE AYAHLLPNGR YPVCILFIEV EPHEVDVNVH
     PTKAEVRFQR DREVRAAVYQ AARHALGAAL LIPGTEVTAD GEVRVPDRAE EKAALQRGWV
     PPGAGRPGEG GGRAAPPPWR VSAGGPGGQT TAREPVQAYL PAGGLQAALA QRAAEEAAAA
     VPAVDLAEAT LVPRSAEPGE LIRALRPLGQ VHRSYIACDG PEGLYLIDQH AAHERIFFER
     LYAAAQEQAT AVQRLLFPLT LDLTPAQMAI WQENAAIFAE SGFEAEPFGG NTLLIHGVPA
     GLGTDHVARL VCDFLDRLQE DQVAPGTPVT DRRRRVLAAM AACKAAIKAR DPLQPEDIAA
     LLSDLAACAS PETCPHGRPT VICVSISELE KRFKR