ID   MUTL_SYNAS              Reviewed;         616 AA.
AC   Q2LUR5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=SYNAS_19460;
GN   ORFNames=SYN_02889;
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophales; Syntrophaceae;
OC   Syntrophus.
OX   NCBI_TaxID=56780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB;
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000252; ABC77825.1; -; Genomic_DNA.
DR   RefSeq; WP_011417846.1; NC_007759.1.
DR   AlphaFoldDB; Q2LUR5; -.
DR   SMR; Q2LUR5; -.
DR   STRING; 56780.SYN_02889; -.
DR   EnsemblBacteria; ABC77825; ABC77825; SYN_02889.
DR   KEGG; sat:SYN_02889; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..616
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010098"
SQ   SEQUENCE   616 AA;  68361 MW;  713045113629BCA3 CRC64;
     MNRRIVLLPE TLTHRIAAGE VVERPASIVK ELLENALDSG ATDINVELER GGCGLIRVAD
     NGSGIFAQDV TLAFARHATS KIAEFDDLYR VRSFGFRGEA LASIASISRT ELVTRTADDL
     AGMRIVVEGG NICEKTEAGC PIGTSITVSR IFDSVPVRKK FLKAEATERA YCLDVITRLS
     LANPEVRIRV FSKGRELCHY PATSRLSERV ALVLGNADAD RLQPIEGETD RVRVTGFASR
     PDFTCATTRQ IYTFVNRRHV RDHLLNHAVM TAYRRVIEPR RYPAVVLYVD LDPADVDVNV
     HPAKLEVRFR QPRTVYEAVV EALSGMLRGM GQSALSLTRY GPAGTAEIGH IPQEDYESRI
     SEALRRYSLA SGSRKMMYGT GTEANPVNKK HFLAERIRGE EIHARESLLL SPAPALPQNS
     FHPVFADLVY LGSLWDSYLI FSVADGMLLI DQHAAHERIL FEKIKKAAER NKTAVQVLLI
     PEILNLSRPD FERFGDVVPL LEQVGIEAEP FGGEEIIIKA LPTLLAHLDP GVLVKDLIAE
     CADRGGGLSL QEKGEKIYAY LACRGAVKAG QKLIREEVAQ LCRDLDATPF AATCPHGRPV
     YVLYPLKDIE RMFRRR