ID   MUTL_SYNC1              Reviewed;         628 AA.
AC   Q3A504;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Pcar_1304;
OS   Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)
OS   (Pelobacter carbinolicus).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Syntrophotaleaceae; Syntrophotalea.
OX   NCBI_TaxID=338963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2380 / NBRC 103641 / GraBd1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chertkov O., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Pelobacter carbinolicus DSM 2380.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000142; ABA88553.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3A504; -.
DR   SMR; Q3A504; -.
DR   STRING; 338963.Pcar_1304; -.
DR   PRIDE; Q3A504; -.
DR   EnsemblBacteria; ABA88553; ABA88553; Pcar_1304.
DR   KEGG; pca:Pcar_1304; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002534; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..628
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010053"
FT   REGION          332..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  70040 MW;  C5F1E5D02C37A58D CRC64;
     MSQKIHILPE SLCNQIAAGE VVERPASVVK ELVENALDAG ASRIQVDVEN GGKRLIRVTD
     NGCGMSREDA FLCLERHATS KVRAEQDLFR LTTLGFRGEA LPSIAAVSRF TLRTRLAEDV
     EGWELVVEGG TVKRSSAAGV PPGTIIEIRN LFFNTPARRK FLRRDETELG HIGETLTRLA
     LSCPEVCFRF MHNGRMLWEV NRQKSLVERA AELLGREAVR DMLPVERQGP EGMRLHGLIS
     SPRLNRSGLG GMFTFINGRF IRDKVVQHAL ADGYRNLLAK GRHPVLVLFL EIDPSQVDVN
     VHPTKHEVRF RQQALVHDFI VKALRDHLQQ VPTSAMPAPG NSPFTVPARE NAASVKPDET
     KPALADTPAA FSAGEGSSRS DVPYPSASQV TETTDSYDAH DSGVEGASTA PPLSEEGLFS
     VTADVRPSEQ TENSGFFASL RLIGQYQNSY LVCQSEKDLI LIDQHAAHER IGFEHLRKQY
     LAGSIERQLL LFPLVLEFDF RLGRIVEEQR DSLFRLGFAL ENFGGNAFAL KELPRMLKEA
     DAERLVRDVV DEFAAIGRSQ AVEIELERIL LKMACHAMVR AHQRLSFDEM QALLDELDKT
     PFSSNCPHGR PTFLRWSLGE LERLFKRA