ID   MUTL_SYNWW              Reviewed;         584 AA.
AC   Q0AYB2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Swol_0977;
OS   Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Syntrophomonadaceae;
OC   Syntrophomonas.
OX   NCBI_TaxID=335541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2245B / Goettingen;
RX   PubMed=21966920; DOI=10.1111/j.1462-2920.2010.02237.x;
RA   Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L.,
RA   McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.;
RT   "The genome of Syntrophomonas wolfei: new insights into syntrophic
RT   metabolism and biohydrogen production.";
RL   Environ. Microbiol. 12:2289-2301(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000448; ABI68292.1; -; Genomic_DNA.
DR   RefSeq; WP_011640397.1; NC_008346.1.
DR   AlphaFoldDB; Q0AYB2; -.
DR   SMR; Q0AYB2; -.
DR   STRING; 335541.Swol_0977; -.
DR   EnsemblBacteria; ABI68292; ABI68292; Swol_0977.
DR   KEGG; swo:Swol_0977; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001968; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..584
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071511"
SQ   SEQUENCE   584 AA;  65987 MW;  C29BB14CE20B1B93 CRC64;
     MAIKLLNDNV INKIAAGEVI ERPASVVKEL LENAIDAASR NIAVKISGAG LDSIEVTDDG
     EGISMEELPL AFLRHATSKI ENEGDLLRIM SMGFRGEALP SIASVSRIDI YSKKEKQEGI
     HCFIEGGKIL DLQYFPGPEG SKIIVSDLFF NTPARKKFLR SPVTEGNNAY ELVIKYALAR
     PDIAISFSNE KRQLFRTPGN GSLNDAVIAI FGRDFLEPLI PVKWEGLSLS ISGLISPPGV
     AKMNRKRQLI FVNQRPIRSP LLYRALDEGY RGLLLAREQP LVILQIAVPP DSIDVNVHPQ
     KSEIRFRDEQ SIFRSLCGLL RDTLNARDYR LQDNLPQNRS QPFYPAAGRK TAKQKVEEQP
     VIPFMHNRKA DKRVEETGGE PWIPFYPEEQ AEGSVSRVYD EFKILGQLWD SYILLEKEQT
     LNIVDQHAAH ERIIYSRLQQ FYAASRGEMQ MLAFPLLMDL SLRDMELLEK NQEILGELGF
     DLQQAGPRSI FLRGTPAIIA GQEREVLFEI LELLAGGQGI NLKNEAIIKM ACKKAVKAGT
     RLDYREMMQI IQELFITDDY KNCPHGRPTI IAWKQADLER MFKR