ID   MUTL_SYNY3              Reviewed;         556 AA.
AC   P73349;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=slr1199;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA17380.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000022; BAA17380.1; ALT_INIT; Genomic_DNA.
DR   PIR; S77533; S77533.
DR   AlphaFoldDB; P73349; -.
DR   IntAct; P73349; 2.
DR   STRING; 1148.1652458; -.
DR   PaxDb; P73349; -.
DR   EnsemblBacteria; BAA17380; BAA17380; BAA17380.
DR   KEGG; syn:slr1199; -.
DR   eggNOG; COG0323; Bacteria.
DR   InParanoid; P73349; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; P73349; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..556
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177983"
SQ   SEQUENCE   556 AA;  62952 MW;  876E39EFFF3D05B0 CRC64;
     MIQVLDRQLV DLIAAGEVID SPLAVVRELV ENALDAGADR ILVRVWWDQW RLEVLDNGQG
     MDVTELKTSV LPHATSKIST QADLQRIKTL GFRGEALHSL AQVARLTISS RSVASPGCGW
     RITYSPQGSP EQIEPVAIAM GTRVEVRQLF ANFPQRRQAF AKSQQFWRPM VTYLQQLALC
     HPQVTWQLWQ DERLRLSLSP GPNPEAILLQ CLKSLQAGQL GYTQQSLSLP VDLENQATSA
     QLSLTFGYPD RCHRPRPDWL IIAINGRPVN VPELTQTILA VFHRTLPRQR YPLCFAHWQL
     PPQCIDWHRH PAKTEIYLQD LPHWQGQLKT LLHQSLAILG NDAPPRLNQL LKAAEPKGVY
     QLQGASSLTE TVLGYPKAFK AIAQVCQTYV VVEHDQGIWL VEQHVAHERV LFEQLQRHWQ
     CLPLEQPLVL QGFNPEQVER LQNLGLEIDP FGEDIWAVRS LPALLQGQEE IIAILRELSQ
     VFSLSTAQAA IACRSAIKNG MELDRIAINK LIEQWQQCDN PHTCPHGRPI YLALDESSLA
     RFFRRNWLVN PKTSGS